ArticleEClinicalMedicine2022
Long-term opioid use and mortality in patients with chronic non-cancer pain: Ten-year follow-up study in South Korea from 2010 through 2019.
Article in EClinicalMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Opioid use and the risk of cancer incidence and mortality: a systematic review.Cancer metastasis reviews · 2025Pooled it
- Review
- Association between prenatal opioid exposure and long-term neurodevelopmental disorders among children: a nationwide cohort study : Prenatal opioid exposure and neurodevelopment.BMC pediatrics · 2026Article
- The impact of opioid prescribing guidelines on opioid dispensation: A systematic review and meta-analysis.Canadian journal of pain = Revue canadienne de la douleur · 2026Review
- Associations Between Common Hip and Knee Osteoarthritis Treatments and All-Cause Mortality.Healthcare (Basel, Switzerland) · 2025Review
- Postoperative joint pain is associated with long-term all-cause mortality after total joint arthroplasty.PloS one · 2025Article
- Pharmacological Treatment of Fibromyalgia Syndrome: A Practice-Based Review.Current pain and headache reports · 2024Review
- Article
- Preliminary Validation of a General Factor Model of Chronic Overlapping Pain Conditions.The journal of pain · 2024Article
- Failed back surgery syndrome-terminology, etiology, prevention, evaluation, and management: a narrative review.Journal of Yeungnam medical science · 2024Article
- Review
- Assessment of Epidemiological Data and Surveillance in Korea Substance Use Research: Insights and Future Directions.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2024Review
- Insomnia disorder and cancer mortality in South Korea: a secondary analysis of musculoskeletal disease cohort.Sleep & breathing = Schlaf & Atmung · 2024Article
- Opioid Prescription and Long-Term Survival Outcomes in Adults: A Nationwide Cohort Study in Korea.Journal of Korean medical science · 2024Article
- Long-Term Reductions in Opioid Medication Use After Spinal Stimulation: A Claims Analysis Among Commercially-Insured Population.Journal of pain research · 2024Article
- Associations of vitamin D status with all-cause and cause-specific mortality in long-term prescription opioid users.Frontiers in nutrition · 2024Article
- Adverse Events of the Long-Term Use of Opioids for Chronic Non-cancer Pain: A Narrative Review.Cureus · 2024Review
- Trends in the prescription of opioids and gabapentinoids in patients with failed back surgery syndrome in Korea: a population-based study.The Korean journal of pain · 2024Article
- Initial opioid prescription characteristics and risk of opioid misuse, poisoning and dependence: retrospective cohort study.BMJ quality & safety · 2023Article
- Determining the Impact of Opioid Policy on Substance Use and Mental Health-Related Harms: Protocol for a Data Linkage Study.JMIR research protocols · 2023Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: We aimed to investigate the prevalence and factors associated with long-term opioid use among patients with chronic non-cancer pain (CNCP). Methods: We extracted data from the National Health Insurance Service (NHIS) database in South Korea. As a nationwide database, the NHIS database contains information regarding all disease diagnoses and prescriptions for any drug and/or procedures. A total of 2.5% of adult patients (≥20 years of age) who were diagnosed with musculoskeletal diseases and CNCP from 2010 to 2019 were selected using a stratified random sampling technique and included in the analysis. Patients who were prescribed opioids continuously for ≥90 days were classified as long-term opioid users. Findings: A total of 19,645,161 patients with CNCP were included in the final analysis. The prevalence of long-term opioid use was 0.47% (95% confidence interval [CI]: 0.46%, 0.48%; 8421/1,808,043) in 2010, which gradually increased to 2.63% (95% CI: 2.61%, 2.66%; 49,846/1,892,913) in 2019. Among the 2010 cohort ( Interpretation: Long-term opioid use increased in patients with CNCP in South Korea from 2010 to 2019. Certain factors were potential risk factors for long-term opioid use. Moreover, long-term opioid use was associated with increased 10-year all-cause mortality among patients with CNCP. Funding: None.
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