Evidence map›Paper›PMID 35875808›Full record

ArticleFrontiers in aging neuroscience2022

Practice Effect of Repeated Cognitive Tests Among Older Adults: Associations With Brain Amyloid Pathology and Other Influencing Factors.

Bang Zheng, Chinedu Udeh-Momoh, Tamlyn Watermeyer, Celeste A de Jager Loots, Jamie K Ford, Catherine E Robb, Parthenia Giannakopoulou, Sara Ahmadi-Abhari, Susan Baker, Gerald P Novak and 2 more

Abstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Observational
  8. Article
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  11. Adolescent Alcohol and the Spectrum of Cognitive Dysfunction in Aging.Advances in experimental medicine and biology · 2025
    Review
  12. Article
  13. Amyloid and SCD jointly predict cognitive decline across Chinese and German cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  14. Article
  15. A Closer Look at Practice Effects in Mild Cognitive Impairment and Alzheimer's Disease.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bang ZhengAgeing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, United Kingdom.
Chinedu Udeh-MomohAgeing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, United Kingdom.
Tamlyn WatermeyerEdinburgh Dementia Prevention, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Celeste A de Jager LootsAgeing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, United Kingdom.
Jamie K FordAgeing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, United Kingdom.
Catherine E RobbAgeing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, United Kingdom.
Parthenia GiannakopoulouAgeing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, United Kingdom.
Sara Ahmadi-AbhariAgeing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, United Kingdom.
Susan BakerJanssen Research and Development LLC, Titusville, NJ, United States.
Gerald P NovakJanssen Research and Development LLC, Titusville, NJ, United States.
Geraint PriceAgeing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, United Kingdom.
Lefkos T MiddletonAgeing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Practice effects (PE), after repeated cognitive measurements, may mask cognitive decline and represent a challenge in clinical and research settings. However, an attenuated practice effect may indicate the presence of brain pathologies. This study aimed to evaluate practice effects on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) scale, and their associations with brain amyloid status and other factors in a cohort of cognitively unimpaired older adults enrolled in the CHARIOT-PRO SubStudy. Materials and Methods: 502 cognitively unimpaired participants aged 60-85 years were assessed with RBANS in both screening and baseline clinic visits using alternate versions (median time gap of 3.5 months). We tested PE based on differences between test and retest scores in total scale and domain-specific indices. Multiple linear regressions were used to examine factors influencing PE, after adjusting for age, sex, education level, Results: Participants' total scale, immediate memory and delayed memory indices were significantly higher in the second test than in the initial test (Cohen's d Conclusion: Significant practice effects on RBANS total scale and memory indices were identified in cognitively unimpaired older adults. The association with amyloid status suggests that practice effects are not simply a source of measurement error but may be informative with regard to underlying neuropathology.

Indexed as

amyloid pathologycognitive testmemoryolder adultspractice effect

Identifiers

PMID35875808
PMCPMC9297730

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.