ArticleFrontiers in aging neuroscience2022
Structural Brain Network Abnormalities in Parkinson's Disease With Freezing of Gait.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Characteristics of brain glucose metabolism in Parkinson's disease patients with freezing of gait: a study based onBMC neurology · 2025Article
- Abnormal Alterations of the White Matter Structural Network in Patients with Herpes Zoster and Postherpetic Neuralgia.Brain topography · 2025Article
- Reduced white matter integrity and disrupted brain network in children with type 2 and 3 spinal muscular atrophy.Journal of neurodevelopmental disorders · 2025Article
- Abnormal topological structure of structural covariance networks based on fractal dimension in noise induced hearing loss.Scientific reports · 2024Article
- Topological disruption of low- and high-order functional networks in presbycusis.Brain communications · 2024Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Diffusion tensor imaging (DTI) studies have investigated white matter (WM) integrity abnormalities in Parkinson's disease (PD). However, little is known about the topological changes in the brain network. This study aims to reveal these changes by comparing PD without freezing of gait (FOG) (PD FOG-), PD with FOG (PD FOG+), and healthy control (HC). Methods: 21 PD FOG+, 34 PD FOG-, and 23 HC were recruited, and DTI images were acquired. The graph theoretical analysis and network-based statistical method were used to calculate the topological parameters and assess connections. Results: PD FOG+ showed a decreased normalized clustering coefficient, small-worldness, clustering coefficient, and increased local network efficiency compared with HCs. PD FOG+ showed decreased centrality, degree centrality, and nodal efficiency in the striatum, frontal gyrus, and supplementary motor area (SMA). PD FOG+ showed decreased connections in the frontal gyrus, cingulate gyrus, and caudate nucleus (CAU). The between centrality of the left SMA and left CAU was negatively correlated with FOG questionnaire scores. Conclusion: This study demonstrates that PD FOG+ exhibits disruption of global and local topological organization in structural brain networks, and the disrupted topological organization can be potential biomarkers in PD FOG+. These new findings may provide increasing insight into the pathophysiological mechanism of PD FOG+.
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