ArticleFrontiers in aging neuroscience2022
Alternation of the Rich-Club Organization of Individual Brain Metabolic Networks in Parkinson's Disease.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- A review of FDG-PET biomarker analysis methods in Parkinson's disease.Journal of Parkinson's disease · 2026Review
- Individual-level metabolic connectivity captures cortical morphology and their coupling strengthens in the ageing brain.European journal of nuclear medicine and molecular imaging · 2026Article
- Individual-level metabolic connectivity captures cortical morphology and their coupling strengthens with age.bioRxiv : the preprint server for biology · 2026Article
- Multimodal metabolic and functional network signatures for diagnosis of parkinson's disease: a PET/MR study.Scientific reports · 2025Article
- FDG-PET-based brain network analysis: a brief review of metabolic connectivity.EJNMMI reports · 2025Review
- Impaired rich-club connectivity in childhood absence epilepsy.Frontiers in neurology · 2023Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The diagnosis of Parkinson's disease (PD) remains challenging. Although Materials and Methods: The data of 49 PD patients and 49 well-matched healthy controls (HCs) were retrieved and assessed. An individual metabolic connectome based on the standard uptake value (SUV) was built using the Jensen-Shannon Divergence Similarity Estimation (JSSE) method to compare the rich-club properties between PD patients and HC. Results: Our results showed the rich-club organization of metabolic networks (normalized rich-club coefficients > 1) in the PD and HC group were within a range of thresholds. Further, patients with PD demonstrated lower strength and degree in rich-club connections compared with HCs (strength: HCs = 55.70 ± 8.52, PDs = 52.03 ± 10.49, Conclusion: Individual metabolic networks combined with rich club analysis indicated that PD patients had decreased rich club connections but similar feeder and local connections compared with HCs, indicating rich club connections as a promising marker for early diagnosis of PD.
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