Evidence map›Paper›PMID 35875533›Full record

ArticleFrontiers in microbiology2022

An Abundant and Diverse New Family of Electron Bifurcating Enzymes With a Non-canonical Catalytic Mechanism.

Gerrit J Schut, Dominik K Haja, Xiang Feng, Farris L Poole, Huilin Li, Michael W W Adams

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. From single step hops to emergent biological phenomena.Journal of inorganic biochemistry · 2026
    Review
  4. Article
  5. An electron-bifurcating "plug" to a protein nanowire in tungsten-dependent aldehyde detoxification.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Review
  7. Bacteria on steroids.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Ferredoxin reduction by hydrogen with iron functions as an evolutionary precursor of flavin-based electron bifurcation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Gerrit J SchutDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, United States.
Dominik K HajaDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, United States.
Xiang FengDepartment of Structural Biology, Van Andel Institute, Grand Rapids, MI, United States.
Farris L PooleDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, United States.
Huilin LiDepartment of Structural Biology, Van Andel Institute, Grand Rapids, MI, United States.
Michael W W AdamsDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, United States.
University of Georgia · USVan Andel Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microorganisms utilize electron bifurcating enzymes in metabolic pathways to carry out thermodynamically unfavorable reactions. Bifurcating FeFe-hydrogenases (HydABC) reversibly oxidize NADH (E'∼-280 mV, under physiological conditions) and reduce protons to H

Indexed as

bioenergenesiselectron bifurcation/confurcationferredoxinflavinHydABChydrogenaseiron–sulfur cluster

Identifiers

PMID35875533
PMCPMC9304861
OpenAlexW4284892966

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.