Evidence map›Paper›PMID 35875355›Full record

ArticleFrontiers in cellular neuroscience2022

Mesial Temporal Lobe Epilepsy (MTLE) Drug-Refractoriness Is Associated With P2X7 Receptors Overexpression in the Human Hippocampus and Temporal Neocortex and May Be Predicted by Low Circulating Levels of miR-22.

Bárbara Guerra Leal, Aurora Barros-Barbosa, Fátima Ferreirinha, João Chaves, Rui Rangel, Agostinho Santos, Cláudia Carvalho, Ricardo Martins-Ferreira, Raquel Samões, Joel Freitas and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. The P2X7 Receptor as a Mechanistic Biomarker for Epilepsy.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Bárbara Guerra LealUnit for Multidisciplinary Research in Biomedicine (UMIB), Instituto de Ciências Biomédicas Abel Salazar-Universidade do Porto (ICBAS-UP), Porto, Portugal.
Aurora Barros-BarbosaLaboratório de Farmacologia e Neurobiologia-Center for Drug Discovery and Innovative Medicines (MedInUP), ICBAS-UP, Porto, Portugal.
Fátima FerreirinhaLaboratório de Farmacologia e Neurobiologia-Center for Drug Discovery and Innovative Medicines (MedInUP), ICBAS-UP, Porto, Portugal.
João ChavesUnit for Multidisciplinary Research in Biomedicine (UMIB), Instituto de Ciências Biomédicas Abel Salazar-Universidade do Porto (ICBAS-UP), Porto, Portugal.
Rui RangelServiço de Neurocirurgia, HSA-CHUP, Porto, Portugal.
Agostinho SantosServiço de Patologia Forense, Instituto Nacional de Medicina Legal e Ciências Forenses-Delegação do Norte (INMLCF-DN), Porto, Portugal.
Cláudia CarvalhoImmunogenetics Laboratory, Molecular Pathology and Immunology Department, ICBAS-UP, Porto, Portugal.
Ricardo Martins-FerreiraUnit for Multidisciplinary Research in Biomedicine (UMIB), Instituto de Ciências Biomédicas Abel Salazar-Universidade do Porto (ICBAS-UP), Porto, Portugal.
Raquel SamõesServiço de Neurologia, Hospital de Santo António-Centro Hospitalar e Universitário do Porto (HSA-CHUP), Porto, Portugal.
Joel FreitasServiço de Neurofisiologia, HSA-CHUP, Porto, Portugal.
João LopesServiço de Neurofisiologia, HSA-CHUP, Porto, Portugal.
João RamalheiraServiço de Neurofisiologia, HSA-CHUP, Porto, Portugal.
Maria Graça LoboLaboratório de Farmacologia e Neurobiologia-Center for Drug Discovery and Innovative Medicines (MedInUP), ICBAS-UP, Porto, Portugal.
António Martins da SilvaUnit for Multidisciplinary Research in Biomedicine (UMIB), Instituto de Ciências Biomédicas Abel Salazar-Universidade do Porto (ICBAS-UP), Porto, Portugal.
Paulo P CostaUnit for Multidisciplinary Research in Biomedicine (UMIB), Instituto de Ciências Biomédicas Abel Salazar-Universidade do Porto (ICBAS-UP), Porto, Portugal.
Paulo Correia-de-SáLaboratório de Farmacologia e Neurobiologia-Center for Drug Discovery and Innovative Medicines (MedInUP), ICBAS-UP, Porto, Portugal.
Universidade do Porto · PTHospital de Santo António · PTNational Legal Medicine Institute · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

hippocampusmesotemporal lobe epilepsymicroRNAsmiR-22P2X7 purinoceptorrefractory epilepsy

Identifiers

PMID35875355
PMCPMC9300956
OpenAlexW4284896252

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.