Evidence map›Paper›PMID 35875231›Full record

ArticleJournal of food science and technology2022

In vitro assessment of histamine and lactate production by a multi-strain synbiotic.

Gerrit Stuivenberg, Brendan Daisley, Polycronis Akouris, Gregor Reid

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of food science and technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Potential effects of probiotics on atherosclerosis.Microbiome research reports · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gerrit StuivenbergCentre for Human Microbiome and Probiotic Research, Lawson Health Research Institute, Room F3-106, 268 Grosvenor Street, PO BOX 5777 STN B, London, ON N6A 4V2 Canada.ORCID 0000-0001-5002-8560
Brendan DaisleyCentre for Human Microbiome and Probiotic Research, Lawson Health Research Institute, Room F3-106, 268 Grosvenor Street, PO BOX 5777 STN B, London, ON N6A 4V2 Canada.
Polycronis AkourisCentre for Human Microbiome and Probiotic Research, Lawson Health Research Institute, Room F3-106, 268 Grosvenor Street, PO BOX 5777 STN B, London, ON N6A 4V2 Canada.
Gregor ReidCentre for Human Microbiome and Probiotic Research, Lawson Health Research Institute, Room F3-106, 268 Grosvenor Street, PO BOX 5777 STN B, London, ON N6A 4V2 Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies suggest histamine and d-lactate may negatively impact host health. As excess histamine is deleterious to the host, the identification of bacterial producers has contributed to concerns over the consumption of probiotics or live microorganisms in fermented food items. Some probiotic products have been suspected of inducing d-lactic-acidosis; an illness associated with neurocognitive symptoms such as ataxia. The goals of the present study were to test the in vitro production of histamine and d-lactate by a 24-strain daily synbiotic and to outline methods that others can use to test for their production. Using enzymatic based assays, no significant production of histamine was observed compared to controls (

Indexed as

Food SafetyHistamineLactateProbioticSynbiotic

Identifiers

PMID35875231
PMCPMC9304488

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.