Evidence map›Paper›PMID 35875125›Full record

ArticleFrontiers in oncology2022

Survival Outcomes of Patients With Stage IB3 Cervical Cancer Who Undergo Abdominal Radical Hysterectomy Versus Radiochemotherapy.

Zhiqiang Li, Qing Yang, Jianxin Guo, Guoqiang Liang, Hui Duan, Shaoguang Wang, Min Hao, Wentong Liang, Donglin Li, Xuemei Zhan and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 1 country.

Zhiqiang LiDepartment of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Qing YangDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Jianxin GuoDepartment of Obstetrics and Gynecology, Daping Hospital, Army Medical University, Chongqing, China.
Guoqiang LiangDepartment of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Hui DuanDepartment of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Shaoguang WangDepartment of Gynecology, Yantai Yuhuangding Hospital, Yantai, China.
Min HaoDepartment of Gynecology, the Second Hospital of Shanxi Medical University, Taiyuan, China.
Wentong LiangDepartment of Obstetrics and Gynecology, Guizhou Provincial People's Hospital, Guizhou, China.
Donglin LiDepartment of Obstetrics and Gynecology, Guizhou Provincial People's Hospital, Guizhou, China.
Xuemei ZhanDepartment of Gynecology, Jiangmen Central Hospital, Jiangmen, China.
Qinghuang XieDepartment of Gynecology, Foshan Women and Children Healthcare Hospital, Foshan, China.
Jinghe LangDepartment of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ping LiuDepartment of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Chunlin ChenDepartment of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Nanfang Hospital · CNGuizhou Provincial People's Hospital · CNSouthern Medical University · CNArmy Medical University · CNChina Medical University · CNFoshan Maternity and Child Health Care Hospital · CNJiangmen Central Hospital · CNSecond Hospital of Shanxi Medical University · CNYuhuangding Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to compare the survival outcomes among stage IB3 cervical cancer patients who undergo abdominal radical hysterectomy (ARH)+pelvic lymphadenectomy ± para-aortic lymph node dissection versus radiochemotherapy (R-CT). Methods: Based on the large number of diagnoses and treatments for cervical cancer in the Chinese database, propensity score matching (PSM) was used to compare the 5-year overall survival (OS) and disease-free survival (DFS) rates of the ARH group and R-CT group. Results: There were 590 patients with stage IB3 cervical cancer according to the FIGO 2018 staging system, with 470 patients in the ARH group and 120 patients in the R-CT group. The ARH and R-CT groups showed different 5-year OS and DFS rates in the total study population, and the 5-year OS and DFS rates in the R-CT group (n = 120) were lower than those in the ARH group (n = 470) (OS: 78.1% vs. 92.1%, p < 0.001; DFS: 71.6% vs. 90.3%, p < 0.001). R-CT was associated with a worse 5-year OS rate (hazard ratio [HR] = 3.401; 95% confidence interval [CI] = 1.875-6.167; p < 0.001) and DFS rate (HR = 3.440; 95% CI = 2.075-5.703; p < 0.001) by Cox multivariate analysis. After 1:3 PSM, the 5-year OS and DFS rates in the R-CT group (n = 108) were lower than those in the RH group (n = 280) (OS: 76.4% vs. 94.0%, p < 0.001; DFS: 69.3% vs. 92.6%, p < 0.001, respectively). R-CT was associated with a worse 5-year OS rate (HR = 4.071; 95% CI = 2.042-8.117; p < 0.001) and DFS rate (HR = 4.450; 95% CI = 2.441-8.113; p < 0.001) by Cox multivariate analysis. Conclusion: Our study found that for FIGO 2018 stage IB3 cervical cancer patients, ARH resulted in better OS and DFS than R-CT.

Indexed as

abdominal radical hysterectomycervical cancerdisease-free survivaloverall survivalradiochemotherapystage IB3 cervical cancer

Identifiers

PMID35875125
PMCPMC9296848
OpenAlexW4283833920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.