Evidence map›Paper›PMID 35875039›Full record

ArticleFrontiers in public health2022

Methemoglobinemia and Delayed Encephalopathy After 5-Bromo-2-Nitropyridine Poisoning: A Rare Case Report.

Longke Shi, Guangcai Yu, Liwen Zhao, Zixin Wen, Yaqian Li, Baotian Kan, Xiangdong Jian

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. An occupational pipe leak poisoning.Frontiers in pharmacology · 2025
    Article
  3. Toxic Encephalopathy and Methemoglobinemia after 5-Amino-2-(trifluoromethyl)pyridine Poisoning.International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Longke ShiSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Guangcai YuSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Liwen ZhaoSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Zixin WenSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Yaqian LiSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Baotian KanSchool of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, China.
Xiangdong JianSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Shandong University · CNQilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

5-bromo-2-nitropyridine, an intermediate in the synthesis of pharmaceutical and pesticide products, is toxic to the human body. However, 5-bromo-2-nitropyridine poisoning has not been previously reported. Here, we report the case of a 40-year-old man who suffered skin and respiratory tract exposure to leaked 5-Bromo-2-nitropyridine at work. After exposure, the patient rapidly developed dizziness, fatigue, nausea, vomiting, chest distress, diffuse cyanosis, and coma. Methemoglobinemia, hemolytic anemia, rhabdomyolysis, and acute renal failure were observed after admission. He improved markedly after treatment, but delayed encephalopathy was confirmed 82 days after the exposure. This case highlights that 5-bromo-2-nitropyridine can be absorbed through the skin and respiratory tract, resulting in methemoglobinemia and delayed encephalopathy.

Indexed as

Anemia, HemolyticBrain DiseasesMethemoglobinemiaAdultHumansMalePyridines5-bromo-2-nitropyridinePyridines5-bromo-2-nitropyridineacute renal failurehemolytic anemiamethemoglobinemiarhabdomyolysistoxic encephalopathy

Identifiers

PMID35875039
PMCPMC9300930
OpenAlexW4284881871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.