Evidence map›Paper›PMID 35874930›Full record

ArticleGastro hep advances2022

Gastrointestinal Manifestations of Coronavirus Disease 2019 Across the United States: A Multicenter Cohort Study.

Ankur P Patel, Troy K Sanders, Preeti Prakash, Jade Law, Sujay Alvencar, Alyssa Choi, Janaki Shah, Karishma Patel, Padmavathi Srivoleti, Kirtan Chauhan and 15 more

Open access · goldAbstract read
In one paragraph

Article in Gastro hep advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 10 institutions in 1 country.

Ankur P PatelVatche & Tamar Manoukian Division of Digestive Diseases, UCLA School of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California.
Troy K SandersVatche & Tamar Manoukian Division of Digestive Diseases, UCLA School of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California.
Preeti PrakashVatche & Tamar Manoukian Division of Digestive Diseases, UCLA School of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California.
Jade LawDivision of Gastroenterology, Department of Medicine, Olive View-UCLA Medical Center, Sylmar, California.
Sujay AlvencarDivision of Gastroenterology, Tufts Medical Center, Boston, Massachusetts.
Alyssa ChoiDivision of Gastroenterology, University of California Irvine, Irvine, California.
Janaki ShahInflammatory Bowel Diseases Center, Washington University in St. Louis, Saint Louis, Missouri.
Karishma PatelDivision of Gastroenterology and Hepatology, Oregon Health & Science University, Portland, Oregon.
Padmavathi SrivoletiDepartment of Medicine, Saint Elizabeth's Medical Center, Brighton, Massachusetts.
Kirtan ChauhanDepartment of Medicine, Baylor College of Medicine, Houston, Texas.
Simcha WeissmanDepartment of Medicine, Hackensack University Medical Center, Hackensack, New Jersey.
Erik HolzwangerDivision of Gastroenterology, Tufts Medical Center, Boston, Massachusetts.
Rohit DhingraDivision of Gastroenterology, Tufts Medical Center, Boston, Massachusetts.
Michelle NguyenDivision of Gastroenterology, Tufts Medical Center, Boston, Massachusetts.
Daniel KimDivision of Gastroenterology, University of California Irvine, Irvine, California.
Tahnee SidhuDepartment of Medicine, Saint Elizabeth's Medical Center, Brighton, Massachusetts.
Christopher StallwoodDepartment of Medicine, Saint Elizabeth's Medical Center, Brighton, Massachusetts.
Aaron DicksteinDivision of Gastroenterology, Tufts Medical Center, Boston, Massachusetts.
Nimisha ParekhDivision of Gastroenterology, University of California Irvine, Irvine, California.
Osama AltayarInflammatory Bowel Diseases Center, Washington University in St. Louis, Saint Louis, Missouri.
Matthew A CiorbaInflammatory Bowel Diseases Center, Washington University in St. Louis, Saint Louis, Missouri.
Jessica YuDivision of Gastroenterology and Hepatology, Oregon Health & Science University, Portland, Oregon.
Lea Ann ChenDivision of Gastroenterology and Hepatology, Rutgers University New Brunswick, New Jersey.
James H TabibianVatche & Tamar Manoukian Division of Digestive Diseases, UCLA School of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California.
Berkeley N LimketkaiVatche & Tamar Manoukian Division of Digestive Diseases, UCLA School of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California.
Tufts Medical Center · USUniversity of California, Los Angeles · USSt. Elizabeth's Medical Center · USUniversity of California, Irvine · USWashington University in St. Louis · USOregon Health & Science University · USBaylor College of Medicine · USHackensack University Medical Center · USOlive View-UCLA Medical Center · USRutgers, The State University of New Jersey · US

Funding

The Study of Families with Heritable Crohn's Disease to Support Rational Design of Microbiota-based TherapiesK23DK119544 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI CHEN, LEA A · 2020 to 2024
$1.1M
NIDDK NIH HHS K23 DK119544
6 · The paper itself

Abstract

Background and Aims: Gastrointestinal (GI) symptoms occur among patients diagnosed with coronavirus disease 2019 (COVID-19), and there is clear evidence that SARS-CoV-2, the causative pathogen, infects the GI tract. In this large, multicenter cohort study, we evaluated variations in gastrointestinal and hepatic manifestations of COVID-19 throughout the United States (US). Methods: Patients hospitalized with a positive COVID-19 test prior to October 2020 were identified at 7 US academic centers. Demographics, presenting symptoms, laboratory data, and hospitalization outcomes were abstracted. Descriptive and regression analyses were used to evaluate GI manifestations and their potential predictors. Results: Among 2031 hospitalized patients with COVID-19, GI symptoms were present in 18.9%; diarrhea was the most common (15.2%), followed by nausea and/or vomiting (12.6%) and abdominal pain (6.0%). GI symptoms were less common in the Western cohort (16.0%) than the Northeastern (25.6%) and Midwestern (26.7%) cohorts. Compared to nonintensive care unit (ICU) patients, ICU patients had a higher prevalence of abnormal aspartate aminotransferase (58.1% vs 37.3%; Conclusion: We present the largest multicenter cohort of patients with COVID-19 across the United States. GI manifestations were common among patients hospitalized with COVID-19, although there was significant variability in prevalence and predictors across the United States.

Indexed as

ALT, alanine aminotransferaseaOR, adjusted odds ratioAST, aspartate aminotransferaseBMI, body mass indexCI, confidence intervalCoronavirus Disease 2019COVID-19COVID-19, coronavirus disease 2019GastrointestinalGI, gastrointestinalICU, intensive care unitOR, odds ratioSARS-CoV-2SD, standard deviationUCLA, University of California Los Angeles

Identifiers

PMID35874930
PMCPMC9293374
OpenAlexW4285807464

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.