Evidence map›Paper›PMID 35874927›Full record

ArticleChemCatChem2021

Direct Conversion of Hydrazones to Amines using Transaminases.

Eve M Carter, Fabiana Subrizi, John M Ward, Tom D Sheppard, Helen C Hailes

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemCatChem, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Engineered Biocatalyst for Enantioselective Hydrazone Reduction.Angewandte Chemie (International ed. in English) · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Eve M CarterDepartment of Chemistry University College London 20 Gordon Street London WC1H 0AJ UK.
Fabiana SubriziDepartment of Chemistry University College London 20 Gordon Street London WC1H 0AJ UK.
John M WardDepartment of Biochemical Engineering University College London Gower Street, Bernard Katz Building London WC1E 6BT UK.ORCID 0000-0002-4415-5544
Tom D SheppardDepartment of Chemistry University College London 20 Gordon Street London WC1H 0AJ UK.ORCID 0000-0002-3455-1164
Helen C HailesDepartment of Chemistry University College London 20 Gordon Street London WC1H 0AJ UK.ORCID 0000-0001-5574-4742
University College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transaminase enzymes (TAms) have been widely used for the amination of aldehydes and ketones, often resulting in optically pure products. In this work, transaminases were directly reacted with hydrazones in a novel approach to form amine products. Several substrates were investigated, including those with furan and phenyl moieties. It was determined that the amine yields increased when an additional electrophile was added to the reaction mixture, suggesting that they can sequester the hydrazine released in the reaction. Pyridoxal 5'-phosphate (PLP), a cofactor for transaminases, and polyethylene glycol (PEG)-aldehydes were both found to increase the yield of amine formed. Notably, the amination of (

Indexed as

aminesbiocatalysisenzymeshydrazonestransaminases

Identifiers

PMID35874927
PMCPMC9292518
OpenAlexW3196490158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.