Evidence map›Paper›PMID 35874784›Full record

ArticleFrontiers in immunology2022

Immune Profiling in Gastric Cancer Reveals the Dynamic Landscape of Immune Signature Underlying Tumor Progression.

Yuhan Wei, Jianwei Zhang, Xueke Fan, Zhi Zheng, Xiaoyue Jiang, Dexi Chen, Yuting Lu, Yingrui Li, Miao Wang, Min Hu and 9 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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  5. International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 2 countries.

Yuhan WeiDepartment of Oncology, Beijing Friendship Hospital, The Second Clinical Medical College of Capital Medical University, Beijing, China.
Jianwei ZhangDepartment of Pancreatic and Gastric Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xueke FanGastroenterology Department, Jincheng People's Hospital, Jincheng, China.
Zhi ZhengDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Xiaoyue JiangDepartment of Oncology, Beijing Friendship Hospital, The Second Clinical Medical College of Capital Medical University, Beijing, China.
Dexi ChenBeijing Institute of Hepatology, Beijing You An Hospital, Capital Medical University, Beijing, China.
Yuting LuDepartment of Oncology, Beijing Friendship Hospital, The Second Clinical Medical College of Capital Medical University, Beijing, China.
Yingrui LiDepartment of Oncology, Beijing Friendship Hospital, The Second Clinical Medical College of Capital Medical University, Beijing, China.
Miao WangDepartment of Oncology, Beijing Friendship Hospital, The Second Clinical Medical College of Capital Medical University, Beijing, China.
Min HuDepartment of Oncology, Beijing Friendship Hospital, The Second Clinical Medical College of Capital Medical University, Beijing, China.
Qi DuDepartment of Oncology, Beijing Friendship Hospital, The Second Clinical Medical College of Capital Medical University, Beijing, China.
Liuting YangBiochemistry and Molecular Biology, Basic Medical College, Shanxi Medical University, Taiyuan, China.
Hongzhong LiChongqing Key Laboratory of Molecular Oncology and Epigenetics, First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yi XiaoDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Yongfu LiDepartment of Oncology, Beijing Friendship Hospital, The Second Clinical Medical College of Capital Medical University, Beijing, China.
Jiangtao JinDepartment of Intervention Therapy, Zezhou People's Hospital, Jincheng, China.
Deying WangDepartment of Technology Innovation, China National Nuclear Corporation (CNNC) Hexin Information Technology (Beijing) Co., Ltd., Beijing, China.
Xiangliang YuanDepartment of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qin LiDepartment of Oncology, Beijing Friendship Hospital, The Second Clinical Medical College of Capital Medical University, Beijing, China.
Capital Medical University · CNBeijing Friendship Hospital · CNBeijing YouAn Hospital · CNChina National Nuclear Corporation · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNFirst Affiliated Hospital of Chongqing Medical University · CNHainan Medical University · CNShanghai Jiao Tong University · CNShanxi Medical University · CNThe University of Texas MD Anderson Cancer Center · USZoucheng People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The profiling of the tumor immune microenvironment (TIME) is critical for guiding immunotherapy strategies. However, how the composition of the immune landscape affects the tumor progression of gastric cancer (GC) is ill-defined. Here, we used mass cytometry to perform simultaneous in-depth immune profiling of the tumor, adjacent tissues, and blood cells from GC patients and revealed a unique GC tumor-immune signature, where CD8

Indexed as

Stomach NeoplasmsCD8-Positive T-LymphocytesHumansImmunophenotypingT-Lymphocytes, RegulatoryTumor Microenvironmentbiomarkergastric cancerimmune profilingPD-1tumor immune microenvironment

Identifiers

PMID35874784
PMCPMC9304688
OpenAlexW4284891229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.