Evidence map›Paper›PMID 35874775›Full record

ReviewFrontiers in immunology2022

Dengue Infection - Recent Advances in Disease Pathogenesis in the Era of COVID-19.

Yean Kong Yong, Won Fen Wong, Ramachandran Vignesh, Indranil Chattopadhyay, Vijayakumar Velu, Hong Yien Tan, Ying Zhang, Marie Larsson, Esaki M Shankar

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Utility of VIDASTropical medicine and infectious disease · 2025
    Article
  8. Article
  9. Recommendations for dengue vaccine implementation in the elderly population.Therapeutic advances in vaccines and immunotherapy · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Yean Kong YongLaboratory Centre, Xiamen University Malaysia, Sepang, Malaysia.
Won Fen WongDepartment of Medical Microbiology, Faculty Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Ramachandran VigneshPreclinical Department, Royal College of Medicine Perak (UniKL RCMP), Universiti Kuala Lumpur, Ipoh, Malaysia.
Indranil ChattopadhyayCancer and Microbiome Biology, Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur, India.
Vijayakumar VeluDivision of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States.
Hong Yien TanSchool of Traditional Chinese Medicine, Xiamen University Malaysia, Sepang, Malaysia.
Ying ZhangChemical Engineering, Xiamen University Malaysia, Sepang, Malaysia.
Marie LarssonMolecular Medicine and Virology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Esaki M ShankarInfection Biology, Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur, India.
Xiamen University Malaysia · MYCentral University of Tamil Nadu · INEmory University · USLinköping University · SEUniversity of Kuala Lumpur · MYUniversity of Malaya · MY

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Viral Testing Core-Maintenance of the SPF Breeding Colonies at Yerkes National Primate Research CenterU42OD011023 · OD · EMORY UNIVERSITY · PI Matthew Ryan Gardner · 2018 to 2026
$17.5M
Combined cytokine therapy for sustained HIV remissionR01AI148377 · NIAID · EMORY UNIVERSITY · PI AMARA, RAMA RAO, VELU, VIJAYAKUMAR · 2020 to 2024
$4.6M
NIAID NIH HHS P30 AI050409NIAID NIH HHS R01 AI148377NIH HHS P51 OD011132NIH HHS U42 OD011023
6 · The paper itself

Abstract

The dynamics of host-virus interactions, and impairment of the host's immune surveillance by dengue virus (DENV) serotypes largely remain ambiguous. Several experimental and preclinical studies have demonstrated how the virus brings about severe disease by activating immune cells and other key elements of the inflammatory cascade. Plasmablasts are activated during primary and secondary infections, and play a determinative role in severe dengue. The cross-reactivity of DENV immune responses with other flaviviruses can have implications both for cross-protection and severity of disease. The consequences of a cross-reactivity between DENV and anti-SARS-CoV-2 responses are highly relevant in endemic areas. Here, we review the latest progress in the understanding of dengue immunopathogenesis and provide suggestions to the development of target strategies against dengue.

Indexed as

COVID-19DengueDengue VirusAntibodies, ViralAntibody-Dependent EnhancementHumansAntibodies, Viralantibody-dependent enhancement (ADE)COVID-19cytokine stormdengue (DENV)endothelial dysfunctioninflammasomepathogenesisplasmablasts

Identifiers

PMID35874775
PMCPMC9299105
OpenAlexW4283833016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.