ArticleFrontiers in immunology2022
Single-Cell RNA Sequencing Unravels Distinct Tumor Microenvironment of Different Components of Lung Adenocarcinoma Featured as Mixed Ground-Glass Opacity.
Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 6 citations in OpenAlex.
- Construction of chronic inflammation and mitochondrial energy metabolism-associated predictive and therapeutic models for lung adenocarcinoma patients.Discover oncology · 2026Article
- Systematic Comparison of Droplet-Based and Microwell-Based Platforms for Comprehensive Single-Cell Transcriptomic Analysis in Clinical Samples.IET nanobiotechnology · 2026Article
- Article
- Spatial downregulation of CD74 signatures may drive invasive component development in part-solid lung adenocarcinoma.iScience · 2023Article
- Multiple primary lung cancer: Updates of clinical management and genomic features.Frontiers in oncology · 2023Review
- Identification of novel gene signature for lung adenocarcinoma by machine learning to predict immunotherapy and prognosis.Frontiers in immunology · 2023Article
- Promising immunotherapeutic targets in lung cancer based on single-cell RNA sequencing.Frontiers in immunology · 2023Review
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Authors and funding
10 authors at 2 institutions in 1 country.
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Abstract
Lung adenocarcinoma featured as mixed ground-glass opacity (mGGO) doubled its volume half of the time in comparison with that featured as pure ground-glass opacity (pGGO). The mechanisms underlying the heterogeneous appearance of mGGO remain elusive. In this study, we macro-dissected the solid (S) components and ground-glass (GG) components of mGGO and performed single-cell sequencing analyses of six paired components from three mGGO patients. A total of 19,391 single-cell profiles were taken into analysis, and the data of each patient were analyzed independently to obtain a common alteration. Cancer cells and macrophages were the dominant cell types in the S and GG components, respectively. Cancer cells in the S components, which showed relatively malignant phenotypes, were likely to originate from both the GG and S components and monitor the surrounding tumor microenvironment (TME) through an intricate cell interaction network.
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