Evidence map›Paper›PMID 35874700›Full record

ArticleFrontiers in immunology2022

An OGT-STAT5 Axis in Regulatory T Cells Controls Energy and Iron Metabolism.

Zengdi Zhang, Oscar C Salgado, Bing Liu, Zahra Moazzami, Kristin A Hogquist, Michael A Farrar, Hai-Bin Ruan

Abstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Adipose-tissue regulatory T cells are a consortium of subtypes that evolves with age and diet.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zengdi ZhangDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, United States.
Oscar C SalgadoCenter for Immunology, University of Minnesota, Minneapolis, MN, United States.
Bing LiuDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, United States.
Zahra MoazzamiDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, United States.
Kristin A HogquistCenter for Immunology, University of Minnesota, Minneapolis, MN, United States.
Michael A FarrarCenter for Immunology, University of Minnesota, Minneapolis, MN, United States.
Hai-Bin RuanDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, United States.

Funding

Intestinal O-GlcNAc signaling and mucosal host defenseR01AI162791 · NIAID · UNIVERSITY OF MINNESOTA · PI Hai-Bin Ruan · 2022 to 2026
$2.4M
Protein O-GlcNAcylation in Regulatory T Cell FunctionR01AI139420 · NIAID · UNIVERSITY OF MINNESOTA · PI RUAN, HAI-BIN · 2019 to 2023
$2.3M
Intestinal O-GlcNAc signaling and mucosal host defenseR56AI162791 · NIAID · UNIVERSITY OF MINNESOTA · PI RUAN, HAI-BIN · 2021 to 2021
$484k
NIAID NIH HHS R01 AI139420NIAID NIH HHS R01 AI162791NIAID NIH HHS R56 AI162791
6 · The paper itself

Abstract

The immunosuppressive regulatory T (Treg) cells exert emerging effects on adipose tissue homeostasis and systemic metabolism. However, the metabolic regulation and effector mechanisms of Treg cells in coping with obesogenic insults are not fully understood. We have previously established an indispensable role of the O-linked N-Acetylglucosamine (O-GlcNAc) signaling in maintaining Treg cell identity and promoting Treg suppressor function,

Indexed as

Insulin ResistanceN-AcetylglucosaminyltransferasesSTAT5 Transcription FactorT-Lymphocytes, RegulatoryAcetylglucosamineAnimalsIronMiceObesityAcetylglucosamineIronN-AcetylglucosaminyltransferasesOgt protein, mouseSTAT5 Transcription Factoradipose tissuefatty acid uptakeironO-GlcNAcTreg - regulatory T cell

Identifiers

PMID35874700
PMCPMC9304952

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.