ReviewFrontiers in behavioral neuroscience2022
Toward Precision Medicine in ADHD.
Review in Frontiers in behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06810180 (Examination of the Dynamic Relationships of Sleep, Physical Activity, and Circadian Rhythmicity With Neurobehavioral Heterogeneity in ADHD), which is not on this map. Cited by 48 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Examination of the Dynamic Relationships of Sleep, Physical Activity, and Circadian Rhythmicity With Neurobehavioral Heterogeneity in ADHD
Who cites it
48 citing papers in PubMed, 4 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Individualized prediction models in ADHD: a systematic review and meta-regression.Molecular psychiatry · 2024Pooled it
- Treatment Outcomes With Licensed and Unlicensed Stimulant Doses for Adults With Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis.JAMA psychiatry · 2024Pooled it
- Nonstimulant Medications for Attention-Deficit/Hyperactivity Disorder (ADHD) in Adults: Systematic Review and Meta-analysis.CNS drugs · 2023Pooled it
- Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD).The Cochrane database of systematic reviews · 2023Pooled it
- Data-driven mechanistic analysis of digital therapeutic-assisted training and evaluation of personalized protocol effects in children with attention deficit/hyperactivity disorder.Frontiers in psychiatry · 2026Trial
- Cortical gyrification predicts initial treatment response in adults with ADHD.Translational psychiatry · 2025Trial
- Examining relationships between delay and probability discounting and perceived stress in a high-income online sample.Journal of behavioral medicine · 2026Article
- Clinical practices in ADHD management across Europe: findings from the ESCAP research academy survey.European child & adolescent psychiatry · 2026Article
- Association Between the Genetic Risk for Attention-Deficit/Hyperactivity Disorder and Cognitive Function in Older Age: The MYHAT Population-Based Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Interrogating cognitive and neural group variation in childhood: Examples in adolescent brain cognitive development and Oregon attention-deficit/hyperactivity disorder-1000 cohorts.Journal of psychopathology and clinical science · 2026Article
- Review
- ADHD medications and preadolescent brain structure: patterns of cortical attenuation from the ABCD study.Scientific reports · 2026Article
- Voices of change: associations between vocal markers and symptoms of ADHD - Findings from the LIFE child study.European child & adolescent psychiatry · 2026Article
- Altered flow of information in attention-deficit/hyperactivity disorder.Translational psychiatry · 2026Article
- Downregulation of integrin α3 in ADHD mirrored in mutant mouse model by dopamine-dependent hippocampal AMPAR expression.Molecular psychiatry · 2026Article
- hiPSC-derived cortical neurons from ADHD individuals reveal dysregulated glutamatergic development.Molecular psychiatry · 2026Article
- Clinical Phenotype Identification in Chinese Children with ADHD Using Latent Profile Analysis and Implications for Precision Nursing Pathways.Psychology research and behavior management · 2026Article
- Functional Variation in RGS12 Should Not Preclude Methylphenidate Use in Bipolar Disorder with Established Mood Stabilization: Preclinical Evidence.International journal of molecular sciences · 2025Article
- Impaired Attention Functioning in Children and Adolescents with Obesity: Preliminary Results Based on the Computerized Continuous Performance Test.Journal of clinical medicine · 2025Article
- Clinical response to a single-dose methylphenidate challenge is indicative of treatment response at two months in adults with ADHD.Translational psychiatry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 19 institutions in 9 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Attention-Deficit Hyperactivity Disorder (ADHD) is a complex and heterogeneous neurodevelopmental condition for which curative treatments are lacking. Whilst pharmacological treatments are generally effective and safe, there is considerable inter-individual variability among patients regarding treatment response, required dose, and tolerability. Many of the non-pharmacological treatments, which are preferred to drug-treatment by some patients, either lack efficacy for core symptoms or are associated with small effect sizes. No evidence-based decision tools are currently available to allocate pharmacological or psychosocial treatments based on the patient's clinical, environmental, cognitive, genetic, or biological characteristics. We systematically reviewed potential biomarkers that may help in diagnosing ADHD and/or stratifying ADHD into more homogeneous subgroups and/or predict clinical course, treatment response, and long-term outcome across the lifespan. Most work involved exploratory studies with cognitive, actigraphic and EEG diagnostic markers to predict ADHD, along with relatively few studies exploring markers to subtype ADHD and predict response to treatment. There is a critical need for multisite prospective carefully designed experimentally controlled or observational studies to identify biomarkers that index inter-individual variability and/or predict treatment response.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.