Evidence map›Paper›PMID 35874643›Full record

ArticleKidney international reports2022

Clinical Efficacy of SARS-CoV-2 Vaccination in Hemodialysis Patients.

Rubén Torres, Luis Toro, María Eugenia Sanhueza, Eduardo Lorca, Mireya Ortiz, Jacqueline Pefaur, Rene Clavero, Eduardo Machuca, Fernando Gonzalez, Patricia Herrera and 37 more

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors at 4 institutions in 3 countries.

Rubén TorresFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Luis ToroFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
María Eugenia SanhuezaFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Eduardo LorcaFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Mireya OrtizFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Jacqueline PefaurFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Rene ClaveroFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Eduardo MachucaFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Fernando GonzalezDivision of Nephrology, Hospital del Salvador, Santiago, Chile.
Patricia HerreraFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Alfredo MocarquerFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Alondra FriasFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Eric RoesslerFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Carolina MuñozFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Miguel NuñezFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Cesar AravenaFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Enrique QuintanaFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Juan LemusFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Mario LilloFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Enrique ReynoldsFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Alvaro MoralesFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Edgard PaisFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Andrea FiabaneFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Alfredo Parra-LucaresDivision of Critical Care Medicine, Department of Medicine, Hospital Clínico Universidad de Chile, Santiago, Chile.
Cristian GarridoDepartment of Radiology, Hospital Clinico Universidad de Chile, Santiago, Chile.
Gabriel Mendez-ValdesFaculty of Medicine, Universidad de Chile, Santiago, Chile.
Eduardo VillaFaculty of Medicine, Universidad de Chile, Santiago, Chile.
Rodrigo MansillaFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Germana SotomayorFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Marcela GonzalezFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Cecilia MirandaFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Eduardo BrionesFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Esteban GomezFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Sergio MezzanoFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Waldo BernalesFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Ximena RoccaFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Oscar EspinozaFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Eric ZuñigaFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Henry AragonFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Marta BadillaFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Marcela ValenzuelaFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Luis EscobarFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Daniela ZamoraFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Ivan FloresFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Beatriz TapiaFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Tamara BorquezFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Patricio HerreraFuerza de Trabajo anti COVID-19, Sociedad Chilena de Nefrología, Chile.
Hospital del Salvador · CLHospital Clínico de la Universidad de Chile · CLUniversity of Chile · CLFresenius Medical Care (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The COVID-19 pandemic is a global public health problem. Patients with end-stage renal disease on hemodialysis are at a higher risk of infection and mortality than the general population. Worldwide, a vaccination campaign has been developed that has been shown to reduce severe infections and deaths in the general population. However, there are currently limited data on the clinical efficacy of vaccinations in the hemodialysis population. Methods: A national multicenter observational cohort was performed in Chile to evaluate the clinical efficacy of anti-SARS-CoV-2 vaccination in end-stage renal disease patients on chronic hemodialysis from February 2021 to August 2021. In addition, the BNT162b2 (Pfizer-BioNTech) and CoronaVac (Sinovac) vaccines were evaluated. The efficacy of vaccination in preventing SARS-CoV-2 infection, hospitalizations, and deaths associated with COVID-19 was determined. Results: A total of 12,301 patients were evaluated; 10,615 (86.3%) received a complete vaccination (2 doses), 490 (4.0%) received incomplete vaccination, and 1196 (9.7%) were not vaccinated. During follow-up, 1362 (11.0%) patients developed COVID-19, and 150 died (case fatality rate: 11.0%). The efficacy of the complete vaccination in preventing infection was 18.1% (95% confidence interval [CI]:11.8-23.8%), and prevention of death was 66.0% (95% CI:60.6-70.7%). When comparing both vaccines, BNT162b2 and CoronaVac were effective in reducing infection and deaths associated with COVID-19. Nevertheless, the BNT162b2 vaccine had higher efficacy in preventing infection (42.6% vs. 15.0%) and deaths (90.4% vs. 64.8%) compared to CoronaVac. Conclusion: The results of our study suggest that vaccination against SARS-CoV-2 in patients on chronic hemodialysis was effective in preventing infection and death associated with COVID-19.

Indexed as

COVID-19epidemiologyhemodialysismortalityrenal dialysisSARS-CoV-2

Identifiers

PMID35874643
PMCPMC9287586
OpenAlexW4285602498

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.