ArticleFrontiers in pediatrics2022
Holder Pasteurization: Comparison of Water-Bath and Dry-Tempering Devices.
Article in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Effect of Holder pasteurization on nutrient and immune component retention in human milk: a comparison between water and dry pasteurizers.International breastfeeding journal · 2025Article
- Human milkFrontiers in nutrition · 2025Review
- New latex agglutination assay for the determination of lactoferrin in human milk.International breastfeeding journal · 2024Article
- New alternatives to holder pasteurization in processing donor milk in human milk banks.Frontiers in nutrition · 2024Review
- A novel heat treatment protocol for human milk.Frontiers in pediatrics · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Human milk (HM) for premature infants is frequently Holder pasteurized (heated at 62.5 ± 0.5°C for 30 min) despite its detrimental effects on heat-sensitive milk components. This tolerated compromise ensures HM's microbial safety while less detrimental methods like short-time HM treatments (HTST) are still being evaluated. Dry-tempering devices (DT-HoP) were recently introduced in clinical practice due to hygienic concerns about water-based Holder pasteurizers (WB-HoP). Evidence on the impact of such dry-tempering devices on HM quality is lacking. The aim of this study was to compare protein retention rates after DT-HoP, WB-HoP and HTST. Methods: We colorimetrically determined alkaline phosphatase activity (ALP), concentrations of secretory immunoglobulin A (sIgA), and lactoferrin (LF) before and after DT-HoP, WB-HoP and HTST. Results: ALP was below the detection limit after HoP, but retained 52.8 ± 13% activity after HTST ( Conclusion: Dry-tempering milk lowers even further the quality of HM when performing HoP compared to water-bath pasteurization, while HTST warrants continued evaluation for clinical application.
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Registered trials
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