Evidence map›Paper›PMID 35874503›Full record

ArticleToxicological research2022

Short- and long-term effect of colorectal cancer targeting peptides conjugated to gold nanoparticles in rats' liver and colon after single exposure.

Olusola B Adewale, Lynn Cairncross, Hlumisa Xakaza, Nicolas Wickens, Scholastica O Anadozie, Hajierah Davids, Saartjie Roux

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicological research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Olusola B AdewaleDepartment of Biochemistry and Microbiology, Nelson Mandela University, Port Elizabeth, 6031 South Africa.ORCID 0000-0001-9837-2838
Lynn CairncrossDepartment of Biochemistry and Microbiology, Nelson Mandela University, Port Elizabeth, 6031 South Africa.
Hlumisa XakazaDepartment of Human Physiology, Nelson Mandela University, Port Elizabeth, 6031 South Africa.
Nicolas WickensDepartment of Medical Laboratory Science, Nelson Mandela University, Port Elizabeth, 6031 South Africa.
Scholastica O AnadozieDepartment of Biochemistry and Microbiology, Nelson Mandela University, Port Elizabeth, 6031 South Africa.
Hajierah DavidsDepartment of Human Physiology, Nelson Mandela University, Port Elizabeth, 6031 South Africa.
Saartjie RouxDepartment of Human Physiology, Nelson Mandela University, Port Elizabeth, 6031 South Africa.
Nelson Mandela University · ZAAfe Babalola University · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peptides play important roles in the diagnosis, prognostic predictors, and treatment of various kinds of cancer. Peptides (p.C, p.L and p.14), derived from the phage display peptide libraries, specifically binds to colorectal cancer (CRC) cells in vitro. To allow tumor specificity and selectivity for in vivo diagnosis of CRC, biotinylated p.C, p.L and p.14 were conjugated to AuNPs (14 nm) via the biotin-streptavidin interaction. Male Wistar rats were intravenously injected with a single dose (100 µg/kg body weight) of AuNPs (citrate-AuNPs, PEG-AuNPs, p.C-PEG-, p.L-PEG- and p.14-PEG-AuNPs). Animals were monitored for behavioral changes, and sacrificed either 14 days or 84 days post-injection. Biochemical changes, oxidative stress, and histology of the liver and colon were assessed. No significant changes were noted in the rats injected with all the AuNPs, except p.L-PEG-AuNPs that caused significant toxicity (

Indexed as

Colorectal cancerDiagnosisGold nanoparticlesPeptidesPolyethylene glycol

Identifiers

PMID35874503
PMCPMC9247135
OpenAlexW3209244185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.