Evidence map›Paper›PMID 35874129›Full record

ReviewFrontiers in surgery2022

Embryology of the Abdominal Wall and Associated Malformations-A Review.

Elisabeth Pechriggl, Michael Blumer, R Shane Tubbs, Łukasz Olewnik, Marko Konschake, René Fortélny, Hannes Stofferin, Hanne Rose Honis, Sara Quinones, Eva Maranillo and 1 more

Abstract readReview
In one paragraph

Review in Frontiers in surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Maternal Risk Factors for Omphalocele.Fetal diagnosis and therapy · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Occludin acts as a dynein adaptor regulating permeability and collateral angiogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Elisabeth PechrigglInstitute of Clinical and Functional Anatomy, Medical University of Innsbruck (MUI), Innsbruck, Austria.
Michael BlumerInstitute of Clinical and Functional Anatomy, Medical University of Innsbruck (MUI), Innsbruck, Austria.
R Shane TubbsDepartment of Neurosurgery, Tulane Center for Clinical Neurosciences, Tulane University School of Medicine, New Orleans, LA, United States.
Łukasz OlewnikDepartment of Anatomical Dissection and Donation, Medical University of Lodz, Lodz, Poland.
Marko KonschakeInstitute of Clinical and Functional Anatomy, Medical University of Innsbruck (MUI), Innsbruck, Austria.
René FortélnyDepartment of General, Visceral, and Oncological Surgery, Wilhelminenspital, Vienna, Austria.
Hannes StofferinInstitute of Clinical and Functional Anatomy, Medical University of Innsbruck (MUI), Innsbruck, Austria.
Hanne Rose HonisInstitute of Clinical and Functional Anatomy, Medical University of Innsbruck (MUI), Innsbruck, Austria.
Sara QuinonesDepartment of Anatomy and Embryology, School of Medicine, Complutense University of Madrid, Madrid, Spain.
Eva MaranilloDepartment of Anatomy and Embryology, School of Medicine, Complutense University of Madrid, Madrid, Spain.
José SanudoDepartment of Anatomy and Embryology, School of Medicine, Complutense University of Madrid, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In humans, the incidence of congenital defects of the intraembryonic celom and its associated structures has increased over recent decades. Surgical treatment of abdominal and diaphragmatic malformations resulting in congenital hernia requires deep knowledge of ventral body closure and the separation of the primary body cavities during embryogenesis. The correct development of both structures requires the coordinated and fine-tuned synergy of different anlagen, including a set of molecules governing those processes. They have mainly been investigated in a range of vertebrate species (e.g., mouse, birds, and fish), but studies of embryogenesis in humans are rather rare because samples are seldom available. Therefore, we have to deal with a large body of conflicting data concerning the formation of the abdominal wall and the etiology of diaphragmatic defects. This review summarizes the current state of knowledge and focuses on the histological and molecular events leading to the establishment of the abdominal and thoracic cavities in several vertebrate species. In chronological order, we start with the onset of gastrulation, continue with the establishment of the three-dimensional body shape, and end with the partition of body cavities. We also discuss well-known human etiologies.

Indexed as

abdominal wallcongenital herniadevelopmental cascadeembryologyhuman

Identifiers

PMID35874129
PMCPMC9300894

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.