Evidence map›Paper›PMID 35874077›Full record

ArticleHeliyon2022

Long-term L-3-n-butylphthalide pretreatment attenuates ischemic brain injury in mice with permanent distal middle cerebral artery occlusion through the Nrf2 pathway.

Mingying Sun, Changchun Jiang, Xiwa Hao, Jiangxia Pang, Chao Chen, Wenping Xiang, Jun Zhang, Shijun Zhao, Po Wang, Shangyong Geng and 3 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Butylphthalide inhibits ferroptosis and ameliorates cerebral Ischaemia-Reperfusion injury in rats by activating the Nrf2/HO-1 signalling pathway.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Mingying SunDepartment of Neurology, Baotou Central Hospital, Inner Mongolia, China.
Changchun JiangDepartment of Neurology, Baotou Central Hospital, Inner Mongolia, China.
Xiwa HaoDepartment of Neurology, Baotou Central Hospital, Inner Mongolia, China.
Jiangxia PangDepartment of Neurology, Baotou Central Hospital, Inner Mongolia, China.
Chao ChenDepartment of Neurology, Baotou Central Hospital, Inner Mongolia, China.
Wenping XiangDepartment of Neurology, Baotou Central Hospital, Inner Mongolia, China.
Jun ZhangDepartment of Neurology, Baotou Central Hospital, Inner Mongolia, China.
Shijun ZhaoDepartment of Neurology, Baotou Central Hospital, Inner Mongolia, China.
Po WangDepartment of Neurology, Baotou Central Hospital, Inner Mongolia, China.
Shangyong GengDepartment of Neurology, Baotou Central Hospital, Inner Mongolia, China.
Hanzhang WangDepartment of Neurology, Baotou Central Hospital, Inner Mongolia, China.
Yuechun LiDepartment of Neurology, Baotou Central Hospital, Inner Mongolia, China.
Baojun WangDepartment of Neurology, Baotou Central Hospital, Inner Mongolia, China.
Baotou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

L-3-n-butylphthalide (NBP), which is used for treatment of mild and moderate acute ischemic stroke, exerts its effects by modulating the Nrf2 pathway. However, it has not been established whether NBP exerts its preventive effects in high-risk ischemic stroke patients through the Nrf2 pathway. We investigated whether NBP exerts its preventive effects through the Nrf2 pathway in long-term NBP pretreated dMCAO mice models. Nrf2

Indexed as

Brain ischemiaL-3-n-butylphthalideNeuroprotectionNrf2 signaling pathwayOxidative stress

Identifiers

PMID35874077
PMCPMC9305368
OpenAlexW4284967849

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.