ArticleCell genomics2022
SNP-to-gene linking strategies reveal contributions of enhancer-related and candidate master-regulator genes to autoimmune disease.
Open access · goldAbstract read
In one paragraph
Article in Cell genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
9.2field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Functionally informed cis and trans proteome-wide association studies prioritize disease-critical genes.Research square · 2026Article
- Functionally informed cis and trans proteome-wide association studies prioritize disease-critical genes.medRxiv : the preprint server for health sciences · 2026Article
- Integrative Analysis of Vitamin D-Associated Genetic Variants Reveals Cis-Regulatory Architecture and Multigenic Mechanisms Underlying Chronic Disease-Relevant Pathways.Human mutation · 2026Article
- Integrating polygenic signals and single-cell multiomics identifies cell-type-specific regulomes critical for immune- and aging-related diseases.Nature aging · 2026Article
- Constructing genotype and phenotype network helps reveal disease heritability and phenome-wide association studies.BMC genomics · 2025Article
- Noncoding rare variant associations with blood traits in 166,740 UK Biobank genomes.Nature genetics · 2025Article
- Exploring the Potential Roles ofInternational journal of molecular sciences · 2025Article
- Genetic Architecture of Ischemic Stroke: Insights from Genome-Wide Association Studies and Beyond.Journal of cardiovascular development and disease · 2025Review
- Understanding genetic variants in context.eLife · 2024Article
- Gene regulatory network inference from CRISPR perturbations in primary CD4Cell genomics · 2024Article
- Article
- Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles.Nature genetics · 2024Article
- Integration of human organoids single-cell transcriptomic profiles and human genetics repurposes critical cell type-specific drug targets for severe COVID-19.Cell proliferation · 2024Article
- The genetic basis of autoimmunity seen through the lens of T cell functional traits.Nature communications · 2024Review
- The PENGUIN approach to reconstruct protein interactions at enhancer-promoter regions and its application to prostate cancer.Nature communications · 2023Article
- Systematic differences in discovery of genetic effects on gene expression and complex traits.Nature genetics · 2023Article
- Gene regulatory network inference from CRISPR perturbations in primary CD4+ T cells elucidates the genomic basis of immune disease.bioRxiv : the preprint server for biology · 2023Article
- Polygenic regression uncovers trait-relevant cellular contexts through pathway activation transformation of single-cell RNA sequencing data.Cell genomics · 2023Article
- Interpreting non-coding disease-associated human variants using single-cell epigenomics.Nature reviews. Genetics · 2023Review
- CVD-associated SNPs with regulatory potential reveal novel non-coding disease genes.Human genomics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Kushal K DeyDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Steven GazalDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Bryce van de GeijnDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Samuel Sungil KimDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Joseph NasserBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Jesse M EngreitzDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Alkes L PriceDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Harvard University · USBroad Institute · USMassachusetts Institute of Technology · USStanford University · US
Funding
Statistical methods for studies of rare variantsR01MH101244 · NIMH · HARVARD MEDICAL SCHOOL · PI Benjamin Michael Neale, ALKES L PRICE · 2013 to 2026
$9.4MStatistical methods to localize disease heritability and identify biological mechanismsR37MH107649 · NIMH · BROAD INSTITUTE, INC. · PI Benjamin Michael Neale · 2019 to 2026
$7.0MMethods for Genome-wide Association Studies in Admixed PopulationsR01HG006399 · NHGRI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI PRICE, ALKES L · 2011 to 2024
$6.3MJoint genomic and statistical analyses of schizophrenia and bipolar to decipher genetic susceptibilityR01MH115676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Roel A Ophoff, Bogdan Pasaniuc · 2018 to 2026
$5.9MPredicting the impact of genetic variants, genes and pathways on human DiseaseU01HG012009 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ALKES L PRICE, Soumya Raychaudhuri · 2021 to 2026
$4.2MFunctionally specialized components of disease heritability in ENCODE dataU01HG009379 · NHGRI · HARVARD SCHOOL OF PUBLIC HEALTH · PI PRICE, ALKES L, RAYCHAUDHURI, SOUMYA · 2017 to 2021
$2.5MMapping enhancer-gene regulation in single cells to connect genetic variants to target genes and cell typesR35HG011324 · NHGRI · STANFORD UNIVERSITY · PI ENGREITZ, JESSE M · 2020 to 2024
$2.3MNetwork-based prediction and validation of causal schizophrenia genes and variantsR01MH109978 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI EGGAN, KEVIN C, KELLIS, MANOLIS · 2016 to 2020
$2.1MSystematic mapping and prediction of gene-enhancer connectionsR00HG009917 · NHGRI · STANFORD UNIVERSITY · PI ENGREITZ, JESSE M · 2020 to 2022
$796kFrom common to rare variant functional architectures of human diseasesK99HG010160 · NHGRI · HARVARD SCHOOL OF PUBLIC HEALTH · PI GAZAL, STEVEN · 2018 to 2019
$164kNew approaches for leveraging single-cell data to identify disease-critical genes and gene setsK99HG012203 · NHGRI · HARVARD SCHOOL OF PUBLIC HEALTH · PI DEY, KUSHAL KUMAR · 2022 to 2022
$109kLeveraging biological pathways, gene networks, and functional annotations to understand the genetic architecture of diseases and complex traitsF31HG010818 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KIM, SAMUEL SUNGIL · 2020 to 2021
$69kNHGRI NIH HHS F31 HG010818NHGRI NIH HHS K99 HG010160NHGRI NIH HHS K99 HG012203NHGRI NIH HHS R00 HG009917NHGRI NIH HHS R01 HG006399NHGRI NIH HHS R35 HG011324NHGRI NIH HHS U01 HG009379NHGRI NIH HHS U01 HG012009NIMH NIH HHS R01 MH101244NIMH NIH HHS R01 MH109978NIMH NIH HHS R01 MH115676NIMH NIH HHS R37 MH107649
Abstract
We assess contributions to autoimmune disease of genes whose regulation is driven by enhancer regions (enhancer-related) and genes that regulate other genes in
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.