Evidence map›Paper›PMID 35873656›Full record

ArticleACS applied nano materials2020

Antibody-Conjugated Barium Titanate Nanoparticles for Cell-Specific Targeting.

Tomas Jordan, Mikaela A O'Brien, Catalina-Paula Spatarelu, Geoffrey P Luke

Abstract read
In one paragraph

Article in ACS applied nano materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. (Ba,Ca)(Ti,Sn)OFrontiers in cellular neuroscience · 2026
    Article
  3. BaTiOPharmaceutics · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Antibody Nanocarriers for Cancer Management.Current opinion in biomedical engineering · 2021
    Article
  10. Article
  11. Advancing Versatile Ferroelectric Materials Toward Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tomas JordanThayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, United States.ORCID 0000-0002-7432-1929
Mikaela A O'BrienThayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, United States.
Catalina-Paula SpatareluThayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, United States.
Geoffrey P LukeThayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, United States; Translational Engineering in Cancer Research Program, Norris Cotton Cancer Center, Lebanon, New Hampshire 03766, United States.

Funding

Remote Neurostimulation with Ultrasound-activated Piezoelectric NanoparticlesR21EY029422 · NEI · DARTMOUTH COLLEGE · PI LUKE, GEOFFREY P. · 2018 to 2019
$634k
NEI NIH HHS R21 EY029422
6 · The paper itself

Abstract

Barium titanate nanoparticles (BTNPs) are gaining popularity in biomedical research because of their piezoelectricity, nonlinear optical properties, and high biocompatibility. However, the potential of BTNPs is limited by the ability to create stable nanoparticle dispersions in water and physiological media. In this work, we report a method of surface modification of BTNPs based on surface hydroxylation followed by covalent attachment of hydrophilic poly(ethylene glycol) (PEG) polymers. This polymer coating allows for additional modifications such as fluorescent labeling, surface charge tuning, or directional conjugation of IgG antibodies. We demonstrate the conjugation of anti-EGFR antibodies to the BTNP surface and show efficient molecular targeting of the nanoparticles to A431 cells. Overall, the reported modifications aim to expand the BTNP applications in molecular imaging, cancer therapy, or noninvasive neurostimulation.

Indexed as

antibody conjugationbarium titanate nanoparticlesfluorescencemolecular targetingpoly(ethylene glycol)surface hydroxylation

Identifiers

PMID35873656
PMCPMC9307239

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.