Evidence map›Paper›PMID 35873600›Full record

ArticleFrontiers in allergy2022

Searching for Genetic Biomarkers for Hereditary Angioedema Due to C1-Inhibitor Deficiency (C1-INH-HAE).

Faidra Parsopoulou, Gedeon Loules, Maria Zamanakou, Dorottya Csuka, Agnes Szilagyi, Maria Kompoti, Grzegorz Porebski, Fotis Psarros, Markus Magerl, Anna Valerieva and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in allergy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Genetic Variants Leading to Urticaria and Angioedema and Associated Biomarkers.The journal of allergy and clinical immunology. In practice · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 5 countries.

Faidra ParsopoulouDepartment of Immunology and Histocompatibility, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Gedeon LoulesCeMIA SA, Larissa, Greece.
Maria ZamanakouCeMIA SA, Larissa, Greece.
Dorottya CsukaDepartment of Internal Medicine and Haematology, Hungarian Angioedema Center of Reference and Excellence, Semmelweis University, Budapest, Hungary.
Agnes SzilagyiDepartment of Internal Medicine and Haematology, Hungarian Angioedema Center of Reference and Excellence, Semmelweis University, Budapest, Hungary.
Maria KompotiDepartment of Immunology and Histocompatibility, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Grzegorz PorebskiDepartment of Clinical and Environmental Allergology, Jagiellonian University Medical College, Krakow, Poland.
Fotis PsarrosDepartment of Allergology, Navy Hospital, Athens, Greece.
Markus MagerlInstitute of Allergology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Anna ValerievaDepartment of Allergology, Clinic of Allergology, University Hospital "Alexandrovska", Medical University of Sofia, Sofia, Bulgaria.
Maria StaevskaDepartment of Allergology, Clinic of Allergology, University Hospital "Alexandrovska", Medical University of Sofia, Sofia, Bulgaria.
Krystyna ObtulowiczDepartment of Clinical and Environmental Allergology, Jagiellonian University Medical College, Krakow, Poland.
Marcus MaurerInstitute of Allergology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Matthaios SpeletasDepartment of Immunology and Histocompatibility, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Henriette FarkasDepartment of Internal Medicine and Haematology, Hungarian Angioedema Center of Reference and Excellence, Semmelweis University, Budapest, Hungary.
Anastasios E GermenisDepartment of Immunology and Histocompatibility, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
University of Thessaly · GRSemmelweis University · HUJagiellonian University · PLMedical University of Sofia · BGAthens Naval & Veterans Hospital · GRFraunhofer Institute for Translational Medicine and Pharmacology · DEFreie Universität Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Existing evidence indicates that modifier genes could change the phenotypic outcome of the causal

Indexed as

C1-inhibitor deficiencyfunctional variantsgenetic biomarkershereditary angioedemalong-term prophylaxisnext-generation sequencingseverity score

Identifiers

PMID35873600
PMCPMC9300820
OpenAlexW4284692383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.