Evidence map›Paper›PMID 35873580›Full record

ArticleFrontiers in pharmacology2022

Network Pharmacology and Experimental Validation to Explore the Mechanism of Qing-Jin-Hua-Tan-Decoction Against Acute Lung Injury.

Shunli Xiao, Lu Liu, Zhengxiao Sun, Xiaoqian Liu, Jing Xu, Zhongyuan Guo, Xiaojie Yin, Fulong Liao, Jun Xu, Yun You and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Shunli XiaoInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Lu LiuInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Zhengxiao SunInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Xiaoqian LiuInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Jing XuInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Zhongyuan GuoCollege of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.
Xiaojie YinInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Fulong LiaoInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Jun XuNational and Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin, China.
Yun YouInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Tiejun ZhangNational and Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNTianjin Institute of Pharmaceutical Research (China) · CNFirst Affiliated Hospital of Henan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Qing-Jin-Hua-Tan-Decoction (QJHTD), a classic famous Chinese ancient prescription, has been used for treatment of pulmonary diseases since Ming Dynasty. A total of 22 prototype compounds of QJHTD absorbed into rat blood were chosen as candidates for the pharmacological network analysis and molecular docking. The targets from the intersection of compound target and ALI disease targets were used for GO and KEGG enrichment analyses. Molecular docking was adopted to further verify the interactions between 22 components and the top 20 targets with higher degree values in the component-target-pathway network.

Indexed as

acute lung injurynetwork pharmacologyneutrophil extracellular trapsQing-Jin-Hua-Tan-Decoctionthrombin

Identifiers

PMID35873580
PMCPMC9304690
OpenAlexW4284896185

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.