Evidence map›Paper›PMID 35873294›Full record

ArticleOpen forum infectious diseases2022

Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Transmission Through Solid Organ Transplantation and Outcomes of Coronavirus Disease 2019 Among Recent Transplant Recipients.

Rebecca J Free, Pallavi Annambhotla, Ricardo M La Hoz, Lara Danziger-Isakov, Jefferson M Jones, Lijuan Wang, Senthil Sankthivel, Marilyn E Levi, Marian G Michaels, Wendi Kuhnert and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Rebecca J FreeCOVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Pallavi AnnambhotlaCOVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Ricardo M La HozDivision of Infectious Diseases and Geographic Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Lara Danziger-IsakovDepartment of Pediatrics, Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio, USA.
Jefferson M JonesCOVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Lijuan WangCOVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Senthil SankthivelCOVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Marilyn E LeviDivision of Transplantation, Health Systems Bureau, Health Resources and Services Administration, Rockville, Maryland, USA.
Marian G MichaelsDivision of Pediatric Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine and UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Wendi KuhnertCOVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
David KlassenUnited Network for Organ Sharing, Richmond, Virginia, USA.
Sridhar V BasavarajuCOVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Ian T KracalikCOVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Centers for Disease Control and Prevention · USChildren's Hospital of Pittsburgh · USCincinnati Children's Hospital Medical Center · USHealth Resources and Services Administration · USThe University of Texas Southwestern Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmissible through lung transplantation, and outcomes among infected organ recipients may be severe. Transmission risk to extrapulmonary organ recipients and recent (within 30 days of transplantation) SARS-CoV-2-infected recipient outcomes are unclear. Methods: During March 2020-March 2021, potential SARS-CoV-2 transmissions through solid organ transplantation were investigated. Assessments included SARS-CoV-2 testing, medical record review, determination of likely transmission route, and recent recipient outcomes. Results: During March 2020-March 2021, approximately 42 740 organs were transplanted in the United States. Forty donors, who donated 140 organs to 125 recipients, were investigated. Nine (23%) donors and 25 (20%) recipients were SARS-CoV-2 positive by nucleic acid amplification test (NAAT). Most (22/25 [88%]) SARS-CoV-2-infected recipients had healthcare or community exposures. Nine SARS-CoV-2-infected donors donated 21 organs to 19 recipients. Of these, 3 lung recipients acquired SARS-CoV-2 infections from donors with negative SARS-CoV-2 testing of pretransplant upper respiratory tract specimens but from whom posttransplant lower respiratory tract (LRT) specimens were SARS-CoV-2 positive. Sixteen recipients of extrapulmonary organs from SARS-CoV-2-infected donors had no evidence of posttransplant COVID-19. All-cause mortality within 45 days after transplantation was 6-fold higher among SARS-CoV-2-infected recipients (9/25 [36%]) than those without (6/100 [6%]). Conclusions: Transplant-transmission of SARS-CoV-2 is uncommon. Pretransplant NAAT of lung donor LRT specimens may prevent transmission of SARS-CoV-2 through transplantation. Extrapulmonary organs from SARS-CoV-2-infected donors may be safely usable, although further study is needed. Reducing recent recipient exposures to SARS-CoV-2 should remain a focus of prevention.

Indexed as

COVID-19donor-derived infectionlower respiratory tractLRTSARS-CoV-2solid organ transplantSOTtransplant-transmitted infection

Identifiers

PMID35873294
PMCPMC9297154
OpenAlexW4229027443

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.