ReviewFrontiers in sports and active living2022
Resistance Training Variables for Optimization of Muscle Hypertrophy: An Umbrella Review.
Review in Frontiers in sports and active living, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Comparative effectiveness and dose-response relationship of exercise-based interventions for muscle mass in older women with sarcopenia: a systematic review and network meta-analysis.Frontiers in medicine · 2026Pooled it
- Optimal resistance training prescriptions to improve muscle strength, physical function, and muscle mass in older adults diagnosed with sarcopenia: a systematic review and meta-analysis.Aging clinical and experimental research · 2025Pooled it
- The Effect of Exercise Intervention on Cognitive Function and Quality of Life With Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.Actas espanolas de psiquiatria · 2025Pooled it
- The effects of French contrast training on lower limb athletic performance in healthy adults: a systematic review and meta-analysis.Frontiers in physiology · 2025Pooled it
- The influence of resistance exercise training prescription variables on skeletal muscle mass, strength, and physical function in healthy adults: An umbrella review.Journal of sport and health science · 2024Pooled it
- Is functional training an efficient approach to improve body composition in older people? A systematic review.Frontiers in physiology · 2023Pooled it
- Pre-workout multi-ingredients or carbohydrate alone promote similar resistance training outcomes in middle-aged adults: a double-blind, randomized controlled trial.Journal of the International Society of Sports Nutrition · 2025Trial
- Sex- and fiber type-specific remodeling of the muscle proteome implicates CSRP3 in resistance training-induced hypertrophy.Nature communications · 2026Article
- The Benefits of Non-Pharmaceutic Interventions on Intrinsic Capacity in Insulin-Resistant Adult and Geriatric Populations-A Narrative Review.Journal of clinical medicine · 2026Review
- Exercise during chemotherapy or chemoradiotherapy and treatment delivery and tumor response outcomes: a scoping review.BMC cancer · 2026Article
- American College of Sports Medicine Position Stand. Resistance Training Prescription for Muscle Function, Hypertrophy, and Physical Performance in Healthy Adults: An Overview of Reviews.Medicine and science in sports and exercise · 2026 · on this mapReview
- Effects of Advanced Resistance Training Systems on Muscle Hypertrophy and Strength in Recreationally Trained Adults: A Systematic Review and Meta-Analysis.Journal of functional morphology and kinesiology · 2026Review
- A practical complex training model for non-athletic populations: a randomized controlled trial on lower-limb power and sprint performance.BMC sports science, medicine & rehabilitation · 2026Article
- Effects of an eight-week French contrast training program on lower-limb explosive power, acceleration, and muscle strength in male college badminton players.Frontiers in physiology · 2026Article
- A professional assessment of training plans for muscle hypertrophy and maximal strength developed by generative artificial intelligence.Biology of sport · 2025Article
- Single-Bout Strength: Acute Mental Health Responses to Resistance Training in Active Adults.Sports (Basel, Switzerland) · 2025Article
- Blood Flow Restriction Training: A Tool to Enhance Rehabilitation and Build Athlete Resiliency.Arthroscopy, sports medicine, and rehabilitation · 2025Article
- Reproducibility and quality of hypertrophy-related training plans generated by GPT-4 and Google Gemini as evaluated by coaching experts.Biology of sport · 2025Article
- Review
- Impact of High-Intensity Sports Practice on Stomatognathic System Function: An Observational Study.Dentistry journal · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This umbrella review aimed to analyze the different variables of resistance training and their effect on hypertrophy, and to provide practical recommendations for the prescription of resistance training programs to maximize hypertrophy responses. A systematic research was conducted through of PubMed/MEDLINE, SPORTDiscus and Web of Science following the preferred reporting items for systematic reviews and meta-analyses statement guidelines. A total of 52 meta-analyses were found, of which 14 met the inclusion criteria. These studies were published between 2009 and 2020 and comprised 178 primary studies corresponding to 4,784 participants. Following a methodological quality analysis, nine meta-analyses were categorized as high quality, presenting values of 81-88%. The remaining meta-analyses were rated as moderate quality, with values between 63-75%. Based on this umbrella review, we can state that at least 10 sets per week per muscle group is optimal, that eccentric contractions seem important, very slow repetitions (≥10 s) should be avoided, and that blood flow restriction might be beneficial for some individuals. In addition, other variables as, exercise order, time of the day and type of periodization appear not to directly influence the magnitude of muscle mass gains. These findings provide valuable information for the design and configuration of the resistance training program with the aim of optimizing muscle hypertrophy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.