Evidence map›Paper›PMID 35873194›Full record

ArticleEClinicalMedicine2022

Assessment of tuberculosis disease activity in people infected with

Inge Kroidl, Mohamed I M Ahmed, Sacha Horn, Christina Polyak, Allahna Esber, Ajay Parikh, Leigh Anne Eller, Hannah Kibuuka, Michael Semwogerere, Betty Mwesigwa and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 4 countries.

Inge KroidlDivision of Infectious Diseases and Tropical Medicine, University Hospital of Munich (LMU), Munich, Germany.
Mohamed I M AhmedDivision of Infectious Diseases and Tropical Medicine, University Hospital of Munich (LMU), Munich, Germany.
Sacha HornDivision of Infectious Diseases and Tropical Medicine, University Hospital of Munich (LMU), Munich, Germany.
Christina PolyakU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Allahna EsberU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Ajay ParikhU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Leigh Anne EllerU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Hannah KibuukaMakerere University Walter Reed Project, Kampala, Uganda.
Michael SemwogerereMakerere University Walter Reed Project, Kampala, Uganda.
Betty MwesigwaMakerere University Walter Reed Project, Kampala, Uganda.
Prossy NaluyimaMakerere University Walter Reed Project, Kampala, Uganda.
Joy Mary KasumbaMakerere University Walter Reed Project, Kampala, Uganda.
Jonah MaswaiU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
John OwuothU.S. Army Medical Research Directorate - Africa, Kisumu, Kenya.
Valentine Sing'oeiU.S. Army Medical Research Directorate - Africa, Kisumu, Kenya.
Eric RonoU.S. Army Medical Research Directorate - Africa, Kisumu, Kenya.
Rebecca LooseDivision of Infectious Diseases and Tropical Medicine, University Hospital of Munich (LMU), Munich, Germany.
Michael HoelscherDivision of Infectious Diseases and Tropical Medicine, University Hospital of Munich (LMU), Munich, Germany.
Julie AkeU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Christof GeldmacherDivision of Infectious Diseases and Tropical Medicine, University Hospital of Munich (LMU), Munich, Germany.
AFRICOS Study Group
LMU Klinikum · DEMakerere University Walter Reed Project · UGHenry M. Jackson Foundation · USUnited States Army Medical Research Directorate - Africa · KEWalter Reed Army Institute of Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Early detection of asymptomatic incipient tuberculosis (TB) could improve clinical outcomes and reduce the spread of Methods: Between Jan 1, 2013 and Aug 31, 2018, 2014 people living with HIV were screened annually for active TB using the Xpert MTB/RIF diagnostic assay in 11 clinics in Kenya, Tanzania, Uganda, and Nigeria. Longitudinal blood mononuclear cell samples from 46 selected patients with active and recurrent tuberculosis, latent infection, or incipient TB were further analysed for Findings: Interpretation: In most cases, progression to active TB disease started 6-12 months before diagnosis by clinical symptoms and sputum occurrence of bacilli. Blood biomarkers could facilitate early detection of incipient TB, improve clinical outcomes, and reduce the transmission of Funding: This work was supported by the President's Emergency Plan for AIDS Relief via a cooperative agreement between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense [W81XWH-11-2-0174, W81XWH-18-2-0040] and by the Bundesministerium für Bildung und Forschung (BmBF) through funding of the Deutsches Zentrum für Infektionsforschung (DZIF, TTU-TB personalized medicine TTU 02_813).

Indexed as

BiomarkerHIVIncipient tuberculosisTuberculosis

Identifiers

PMID35873194
PMCPMC9305001
OpenAlexW4285097227

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.