Evidence map›Paper›PMID 35873018›Full record

ArticleGenes & diseases2022

Defective claudin-10 causes a novel variation of HELIX syndrome through compromised tight junction strand assembly.

Sebastian Sewerin, Jörg Piontek, Ria Schönauer, Sonja Grunewald, Angelika Rauch, Steffen Neuber, Carsten Bergmann, Dorothee Günzel, Jan Halbritter

Open access · diamondAbstract read
In one paragraph

Article in Genes & diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The role of claudins in homeostasis.Nature reviews. Nephrology · 2023
    Review
  6. Review
  7. Article
  8. Frontiers in physiology · 2023
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sebastian SewerinDivision of Nephrology, University of Leipzig Medical Center, Leipzig 04103, Germany.
Jörg PiontekClinical Physiology/ Nutritional Medicine, Charité - Universitätsmedizin Berlin, Berlin 12203, Germany.
Ria SchönauerDivision of Nephrology, University of Leipzig Medical Center, Leipzig 04103, Germany.
Sonja GrunewaldDivision of Dermatology, Venereology, and Allergology, University of Leipzig Medical Center, Leipzig 04103, Germany.
Angelika RauchDivision of Prosthodontics and Materials Science, University of Leipzig Medical Center, Leipzig 04103, Germany.
Steffen NeuberCenter for Human Genetics, Bioscientia, Ingelheim 55218, Germany.
Carsten BergmannCenter for Human Genetics, Bioscientia, Ingelheim 55218, Germany.
Dorothee GünzelClinical Physiology/ Nutritional Medicine, Charité - Universitätsmedizin Berlin, Berlin 12203, Germany.
Jan HalbritterDivision of Nephrology, University of Leipzig Medical Center, Leipzig 04103, Germany.
Leipzig University · DECharité - Universitätsmedizin Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Formation of claudin-10 based tight junctions (TJs) is paramount to paracellular Na

Indexed as

Claudin-10HELIX syndromeParacellular transportSalt-losing tubulopathyTight junction

Identifiers

PMID35873018
PMCPMC9293720
OpenAlexW3184152859

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.