Evidence map›Paper›PMID 35872806›Full record

ArticleChemical science2022

Efficient visible/NIR light-driven uncaging of hydroxylated thiazole orange-based caged compounds in aqueous media.

Ryu Hashimoto, Masafumi Minoshima, Souhei Sakata, Fumihito Ono, Hirokazu Ishii, Yuki Watakabe, Tomomi Nemoto, Saeko Yanaka, Koichi Kato, Kazuya Kikuchi

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ryu HashimotoDivision of Applied Chemistry, Graduate School of Engineering, Osaka University 2-1 Yamadaoka Suita Osaka 565-0871 Japan kkikuchi@mls.eng.osaka-u.ac.jp.
Masafumi MinoshimaDivision of Applied Chemistry, Graduate School of Engineering, Osaka University 2-1 Yamadaoka Suita Osaka 565-0871 Japan kkikuchi@mls.eng.osaka-u.ac.jp.ORCID https://orcid.org/0000-0002-9352-3454
Souhei SakataDepartment of Physiology, Faculty of Medicine, Osaka Medical and Pharmaceutical University 2-7, Daigakucho Takatsuki Osaka 569-8686 Japan.
Fumihito OnoDepartment of Physiology, Faculty of Medicine, Osaka Medical and Pharmaceutical University 2-7, Daigakucho Takatsuki Osaka 569-8686 Japan.
Hirokazu IshiiExploratory Research Center on Life and Living Systems (ExCELLS), National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences 5-1 Higashiyama, Myodaiji Okazaki 444-8787 Japan.ORCID https://orcid.org/0000-0001-8391-194X
Yuki WatakabeExploratory Research Center on Life and Living Systems (ExCELLS), National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences 5-1 Higashiyama, Myodaiji Okazaki 444-8787 Japan.ORCID https://orcid.org/0000-0002-6580-1007
Tomomi NemotoExploratory Research Center on Life and Living Systems (ExCELLS), National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences 5-1 Higashiyama, Myodaiji Okazaki 444-8787 Japan.ORCID https://orcid.org/0000-0001-6102-1495
Saeko YanakaExploratory Research Center on Life and Living Systems (ExCELLS), Institute for Molecular Science (IMS), National Institutes of Natural Sciences 5-1 Higashiyama, Myodaiji Okazaki 444-8787 Japan.ORCID https://orcid.org/0000-0002-3513-5701
Koichi KatoExploratory Research Center on Life and Living Systems (ExCELLS), Institute for Molecular Science (IMS), National Institutes of Natural Sciences 5-1 Higashiyama, Myodaiji Okazaki 444-8787 Japan.ORCID https://orcid.org/0000-0001-7187-9612
Kazuya KikuchiDivision of Applied Chemistry, Graduate School of Engineering, Osaka University 2-1 Yamadaoka Suita Osaka 565-0871 Japan kkikuchi@mls.eng.osaka-u.ac.jp.ORCID https://orcid.org/0000-0001-7103-1275
National Institutes of Natural Sciences · JPThe University of Osaka · JPOsaka University of Pharmaceutical Sciences · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In photoactivation strategies with bioactive molecules, one-photon visible or two-photon near-infrared light-sensitive caged compounds are desirable tools for biological applications because they offer reduced phototoxicity and deep tissue penetration. However, visible-light-sensitive photoremovable protecting groups (PPGs) reported so far have displayed high hydrophobicity and low uncaging cross sections (

Identifiers

PMID35872806
PMCPMC9241960
OpenAlexW4285252945

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.