Evidence map›Paper›PMID 35872763›Full record

ArticleFrontiers in medicine2022

Gut Microbiota Structure and Metabolites, Before and After Treatment in Early Rheumatoid Arthritis Patients: A Pilot Study.

Massimiliano Marazzato, Cristina Iannuccelli, Maria Paola Guzzo, Lucia Nencioni, Bruno Lucchino, Giulia Radocchia, Chiara Gioia, Giulia Bonfiglio, Bruna Neroni, Francesca Guerrieri and 6 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Massimiliano MarazzatoDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Cristina IannuccelliEarly Arthritis Clinic, Department of Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Maria Paola GuzzoEarly Arthritis Clinic, Department of Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Lucia NencioniDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Bruno LucchinoEarly Arthritis Clinic, Department of Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Giulia RadocchiaDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Chiara GioiaEarly Arthritis Clinic, Department of Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Giulia BonfiglioDepartment of Diagnostic Medicine and Radiology, UOC Clinical Pathology, Policlinico Umberto I, Rome, Italy.
Bruna NeroniDepartment of Diagnostic Medicine and Radiology, UOC Clinical Pathology, Policlinico Umberto I, Rome, Italy.
Francesca GuerrieriUMR INSERM U1052/CNRS 5286, Cancer Research Center of Lyon, Lyon, France.
Fabrizio PantanellaDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Stefania GarzoliDepartment of Chemistry and Technology of Drug, Sapienza University of Rome, Rome, Italy.
Marta VomeroEarly Arthritis Clinic, Department of Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Cristiana BarbatiEarly Arthritis Clinic, Department of Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Manuela Di FrancoEarly Arthritis Clinic, Department of Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Serena SchippaDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITPoliclinico Umberto I · ITCentre de Recherche en Cancérologie de Lyon · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease. Modifications of gut microbiota seem to be associated with the disease, but the impact of gut microbiota on therapies' outcome remains unclear. A role of T cells in RA pathogenesis has been addressed, particularly on the Th17/Treg cells balance. Our study aimed to evaluate in early RA (ERA) patients compared to a control group, fecal gut microbiota composition, short-chain fatty acids concentrations, and the levels of circulating Th17/Treg and their own cytokines, before and after 3 months of standard treatment (Methotrexate (MTX) plus glucocorticoids). Fecal microbiota characterization was carried out on 19 ERA patients and 20 controls matched for sex and age. Significant decreased biodiversity levels, and a partition on the base of the microbiota composition, between the ERA patients at baseline compared to controls, were observed. The co-occurrent analysis of interactions revealed a characteristic clustered structure of the microbial network in controls that is lost in ERA patients where an altered connection between microbes and clinical parameters/metabolites has been reported. Microbial markers such as

Indexed as

gut microbiota (GM)metabolomicsmethotrexatemicrobial networkrheumatoid arthritis

Identifiers

PMID35872763
PMCPMC9304627
OpenAlexW4284891747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.