Evidence map›Paper›PMID 35872506›Full record

ArticleJournal of neuroimmunology2022

The neutrophil-to-lymphocyte ratio is associated with intubation in pediatric anti-NMDA receptor encephalitis: A retrospective study.

Nisha Kashyap, Morgan Morris, Leah B Loerinc, Macarthur Benoit, Laura Blackwell, Robyn Howarth, Grace Gombolay

Abstract read
In one paragraph

Article in Journal of neuroimmunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nisha KashyapChildren's Healthcare of Atlanta, Division of Neurology, Atlanta, GA, United States of America.
Morgan MorrisEmory University School of Medicine, Department of Pediatrics, Division of Neurology, Atlanta, GA, United States of America.
Leah B LoerincEmory University School of Medicine, 100 Woodruff Circle, Atlanta, GA 30322, USA.
Macarthur BenoitChildren's Healthcare of Atlanta, Division of Neurology, Atlanta, GA, United States of America.
Laura BlackwellEmory University School of Medicine, Department of Pediatrics, Division of Neurology, Atlanta, GA, United States of America; Department of Neuropsychology, Children's Healthcare of Atlanta, Atlanta 30322, Georgia.
Robyn HowarthEmory University School of Medicine, Department of Pediatrics, Division of Neurology, Atlanta, GA, United States of America; Department of Neuropsychology, Children's Healthcare of Atlanta, Atlanta 30322, Georgia.
Grace GombolayChildren's Healthcare of Atlanta, Division of Neurology, Atlanta, GA, United States of America; Emory University School of Medicine, 100 Woodruff Circle, Atlanta, GA 30322, USA. Electronic address: grace.yoonheekim.gombolay@emory.edu.

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Institutional Career Development CoreKL2TR002381 · NCATS · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Anandi Nayan Sheth · 2017 to 2026
$14.1M
Neuro HPA Project 1U54AG062334 · NIA · EMORY UNIVERSITY · PI Ighovwerha Ofotokun · 2018 to 2026
$12.2M
NCATS NIH HHS KL2 TR002381NCATS NIH HHS UL1 TR002378NIA NIH HHS U54 AG062334
6 · The paper itself

Abstract

Background The neutrophil-to-lymphocyte ratio (NLR) may predict poor outcomes in adult anti-NMDAR encephalitis (NMDARE). The association of NLR with outcomes in pediatric NMDARE was examined. Methods Pediatric NMDARE patients (N = 36) were retrospectively studied. Results High NLR (>6) had a higher proportion of tumors (43% versus 7%) and higher intubation rates (100% versus 38%, p = 0.008). Multivariate analyses showed that high NLR did not correlate with one-year outcomes, inpatient length of stay (LOS), or with tumor, but was associated with intubation and rehabilitation LOS. Conclusion NLR is associated with intubation and rehabilitation LOS. Further investigation is needed for prognostic biomarkers in NMDARE.

Indexed as

Anti-N-Methyl-D-Aspartate Receptor EncephalitisAdultChildHumansIntubation, IntratrachealLymphocytesNeutrophilsReceptors, N-Methyl-D-AspartateRetrospective StudiesReceptors, N-Methyl-D-AspartateAnti-NMDA receptor antibodiesAnti-NMDA receptor encephalitisAutoimmune encephalitisNeutrophil to lymphocyte ratioPediatric autoimmune encephalitis

Identifiers

PMID35872506
PMCPMC9675910

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.