Evidence map›Paper›PMID 35872437›Full record

ArticleNeuroImage. Clinical2022

Brain structural alterations in autism and criminal psychopathy.

Tuomo Noppari, Lihua Sun, Lasse Lukkarinen, Vesa Putkinen, Pekka Tani, Nina Lindberg, Emma Saure, Hannu Lauerma, Jari Tiihonen, Niina Venetjoki and 5 more

Abstract read
In one paragraph

Article in NeuroImage. Clinical, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Cortical thickness abnormalities in autism spectrum disorder.European child & adolescent psychiatry · 2024
    Pooled it
  2. Pooled it
  3. Article
  4. Aberrant type 2 dopamine and mu-opioid receptor availability in autism spectrum disorder.European journal of nuclear medicine and molecular imaging · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tuomo NoppariTurku PET Centre, University of Turku, Turku, Finland; Department of Psychiatry, Helsinki University Hospital, Helsinki, Finland. Electronic address: tuomo.noppari@hus.fi.
Lihua SunTurku PET Centre, University of Turku, Turku, Finland; Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Lasse LukkarinenTurku PET Centre, University of Turku, Turku, Finland.
Vesa PutkinenTurku PET Centre, University of Turku, Turku, Finland.
Pekka TaniDepartment of Psychiatry, Helsinki University Hospital, Helsinki, Finland.
Nina LindbergDepartment of Forensic Psychiatry, Helsinki University Hospital, Helsinki, Finland.
Emma SaureDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland; BABA Center and Department of Clinical Neurophysiology, Children's Hospital, Helsinki University Hospital and University of Helsinki, Finland.
Hannu LauermaPsychiatric Hospital for Prisoners, Health Care Services for Prisoners, Turku, Finland; Department of Forensic Psychiatry, Turku University Central Hospital, Finland.
Jari TiihonenDepartment of Clinical Neuroscience, Karolinska Institute and Center for Psychiatry Research, Stockholm, Sweden; Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland; Neuroscience Center, University of Helsinki, Helsinki, Finland.
Niina VenetjokiPsychiatric Hospital for Prisoners, Health Care Services for Prisoners, Turku, Finland.
Marja SalomaaPsychiatric Hospital for Prisoners, Health Care Services for Prisoners, Turku, Finland.
Päivi RautioPsychiatric Hospital for Prisoners, Health Care Services for Prisoners, Turku, Finland.
Jussi HirvonenDepartment of Radiology, Turku University Hospital, Turku, Finland.
Juha SalmiDepartment of Neuroscience and Biomedical Engineering, School of Science, Aalto University, Espoo, Finland.
Lauri NummenmaaTurku PET Centre, University of Turku, Turku, Finland; Department of Psychology, University of Turku, Turku, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The goal of this study was to elucidate the anatomical brain basis of social cognition through two disorders with distinctively different phenotypes of social interaction. We compared structural MR images of 20 individuals with autism spectrum disorder (ASD), 19 violent offenders with high psychopathic traits, and 19 control participants using voxel-based morphometry (VBM). Our earlier study showed lower grey matter volume (GMV) values in the insula, frontal cortex, and sensorimotor cortex of the offender group compared to controls. In the present study, the images of the ASD group revealed lower GMV in the left precuneus, right cerebellum, and right precentral gyrus in comparison with controls. The comparison between the offender and ASD groups showed lower GMV values for the right temporal pole and left inferior frontal gyrus in the offender group. There was also an overlap of both disorders in the right pre-central cortex, showing lower GMV compared to controls. Our findings suggest structural differences between violent offenders with high psychopathy traits and ASD individuals in the frontotemporal social brain network areas, previously associated with empathy. We also provide evidence of similar abnormal structures in the motor cortex for both of these disorders, possibly related to uniting issues of social cognition.

Indexed as

Autism Spectrum DisorderAutistic DisorderCriminalsBrainGray MatterHumansMagnetic Resonance ImagingEmpathyFrontotemporal cortexPre-motor cortexSocial brain networksSocial cognitionVoxel-based morphometry

Identifiers

PMID35872437
PMCPMC9421457

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.