Evidence map›Paper›PMID 35872217›Full record

ReviewThe journal of allergy and clinical immunology. In practice2022

Electronic Cigarettes: A Pro-Con Review of the Current Literature.

Coral X Giovacchini, Laura E Crotty Alexander, Loretta G Que

Open access · bronzeAbstract readReview
In one paragraph

Review in The journal of allergy and clinical immunology. In practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Policy influences on adolescent risk perceptions of vaping.Journal of epidemiology and community health · 2025
    Article
  7. Article
  8. Article
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  12. NAM journal · 2025
    Article
  13. Article
  14. Review
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  16. Review
  17. Article
  18. Article
  19. Article
  20. Electronic Cigarette Harms: Aggregate Evidence Shows Damage to Biological Systems.International journal of environmental research and public health · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Coral X GiovacchiniDivision of Pulmonary, Allergy, and Critical Care, Duke University Health System, Durham, NC.
Laura E Crotty AlexanderPulmonary Critical Care Section, VA San Diego Healthcare System, San Diego, Calif; Division of Pulmonary, Critical Care, Sleep, and Physiology, University of California San Diego, San Diego, Calif. Electronic address: loretta.que@duke.edu.
Loretta G QueDivision of Pulmonary, Allergy, and Critical Care, Duke University Health System, Durham, NC. Electronic address: loretta.que@duke.edu.
Duke University Health System · USUniversity of California System · US

Funding

SANDIA: Supplementing L-citrulline to overweight late Asthma oNset phenotypes to increase airway L-arginine/ADMA ratio and Improve Asthma controlR01HL146542 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI HOLGUIN, FERNANDO, QUE, LORETTA G · 2019 to 2023
$3.6M
Mitochondrial Redox Perturbations in Obese Allergic AsthmaR01HL136917 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ANATHY, VIKAS, DIXON, ANNE E · 2018 to 2022
$3.6M
CXCL10/CXCR3 regulation of ozone-induced epithelial permeabilityR01ES027574 · NIEHS · DUKE UNIVERSITY · PI TIGHE, ROBERT MATTHEW · 2018 to 2022
$3.1M
Oxidative Stress and Regional Airway Remodeling and Fibrosis in Obese AsthmaR01HL153641 · NHLBI · DUKE UNIVERSITY · PI QUE, LORETTA G · 2020 to 2023
$3.0M
Convergence of Vitamin E, THC, Nicotine, Propylene Glycol and Glycerin Effects on Lung Inflammation When VapedK24HL155884 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Laura Elise Crotty Alexander · 2022 to 2026
$609k
BLRD VA I01 BX004767NHLBI NIH HHS K24 HL155884NHLBI NIH HHS R01 HL146542NHLBI NIH HHS R01 HL153641NIEHS NIH HHS R01 ES027574
6 · The paper itself

Abstract

Electronic cigarettes (e-cigarettes, e-cigs, or electronic nicotine delivery systems) are battery-operated devices typically containing glycerol and/or propylene glycol-based solutions with varying nicotine content, known as e-liquids. Although e-cigarettes were originally developed as a potentially less harmful alternative to traditional combustible tobacco cigarette smokers, several factors have driven their popularity among smokers and nonsmokers alike, including their sleek product designs, innumerable appealing flavors, lack of combustible smoke and odor, and high potential nicotine concentrations. Furthermore, many advocates have promoted the idea that e-cigarettes are safe to use, or at least safer than conventional tobacco, despite limited longitudinal data to support these claims. Here, we examine what is known about the impacts of e-cigarette use on traditional cigarette smoking cessation, lung health, and youth and young adult tobacco product exposure. Upon review of the currently available literature, the negative effects of e-cigarette use seem to outweigh any potential benefit, because the available evidence does not confirm the use of e-cigarettes as an effective strategy for supporting traditional combustible tobacco cigarette smoking cessation, particularly given the emerging adverse effects on lung health and the potential future public health effects of e-cigarette adoption among a burgeoning new generation of tobacco product users.

Indexed as

Electronic Nicotine Delivery SystemsSmoking CessationAdolescentHumansNicotinePublic HealthSmokersYoung AdultNicotineDual useE-cigaretteEVALINicotineSmoking cessation

Identifiers

PMID35872217
PMCPMC12922728
OpenAlexW4286268000

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.