ArticleClinical nutrition ESPEN2022
Vitamin D deficiency predicts 30-day hospital mortality of adults with COVID-19.
Article in Clinical nutrition ESPEN, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- The bounds of meta-analytics and an alternative method.Epidemiology and health · 2024Pooled it
- Article
- Associations between pre-infection serum vitamin D concentrations and Omicron COVID-19 incidence, severity and reoccurrence in elderly individuals.Public health nutrition · 2024Article
- Assessment of Supplementation with Different Biomolecules in the Prevention and Treatment of COVID-19.Nutrients · 2024Review
- Association between vitamin D deficiency and post-acute outcomes of SARS-CoV-2 infection.European journal of nutrition · 2024Article
- Low vitamin D levels predict outcomes of COVID-19 in patients with both severe and non-severe disease at hospitalization.Endocrine · 2023Article
- Re: Vitamin D deficiency predicts 30-day hospital mortality of adults with COVID-19.Clinical nutrition ESPEN · 2023Article
- Review
- COVID-19 Prevention: Vitamin D Is Still a Valid Remedy.Journal of clinical medicine · 2022Article
- Vitamin D Supplementation and COVID-19 Outcomes: Mounting Evidence and Fewer Doubts.Nutrients · 2022Article
- Clinical and Prognostic Significance of Baseline Serum Vitamin D Levels in Hospitalized Egyptian Covid-19 Patients.International journal of general medicine · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsSeveral studies have shown conflicting results for the relationship between vitamin D deficiency and COVID-19 outcomes. Here, we aimed to evaluate whether plasma 25(OH)D levels predict mortality in adults admitted with COVID-19, considering potential confounders.
methodsWe conducted a retrospective cohort study that included 115 adults (age 62.1 ± 17.6 years, 65 males) admitted to a Brazilian public hospital for severely symptomatic COVID-19. Subjects were classified into two groups according to their plasma levels of 25(OH)D: sufficiency (≥50 nmol/L) and the deficiency (<50 nmol/L). The diagnosis of COVID-19 was performed using real-time polymerase chain reaction (qPCR). In addition, direct competitive chemiluminescence immunoassay assessed serum 25(OH)D levels.
resultsThe all-cause 30-day mortality was 13.8% (95% CI: 6.5%-21%) in the group of patients with sufficient plasma 25(OH)D levels and 32.1% (95% CI: 14.8%-49.4%) among those with deficient plasma 25(OH)D levels. Cox regression showed that plasma 25(OH)D levels remained a significant predictor of mortality even after adjusting for the covariates sex, age, length of the delay between symptom onset and hospitalization, and disease severity (HR = 0.98, 95% CI: 0.96-1.00; p = 0.02).
conclusionVitamin D deficiency predicts higher mortality risk in adults with COVID-19.
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