Evidence map›Paper›PMID 35871702›Full record

Trial reportClinical oral investigations2022

Photobiomodulation therapy and 3% potassium nitrate gel as treatment of cervical dentin hypersensitivity: a randomized clinical trial.

Andrea Barros Tolentino, Livia Favaro Zeola, Marcella Rodrigues Ueda Fernandes, Claudio Mendes Pannuti, Paulo Vinícius Soares, Ana Cecilia Correa Aranha

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06417580 (Effect of Experimental Pregabalin Gel in Controlling Cervical Dentin Hypersensitivity), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06417580 phase2unknown statusnot on this mapstarted 2024, after this paper: background citation

Effect of Experimental Pregabalin Gel in Controlling Cervical Dentin Hypersensitivity: a Randomized, Double-blind, Controlled Clinical Study

TypeinterventionalSponsorJesuína Lamartine Nogueira AraújoRan2024 to 2024Enrolled18ConditionsDentin SensitivityArmsPlacebo Treatment, Nitrate Potassium Treatment, Pregabalin Treatment
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Review
  8. Photobiomodulation therapy.JADA foundational science · 2025
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Andrea Barros TolentinoDepartment of Restorative Dentistry, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes 2227, São Paulo, 05508-000, Brazil.
Livia Favaro ZeolaDepartment of Dentistry and Dental Materials, School of Dentistry, Federal University of Minas Gerais, Rua Prof. Moacir Gomes de Freitas, 688, Belo Horizonte, Minas Gerais, Brazil.
Marcella Rodrigues Ueda FernandesSpecial Laboratory of Lasers in Dentistry (LELO), Department of Restorative Dentistry, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes 2227, São Paulo, 05508-000, Brazil.
Claudio Mendes PannutiDepartment of Periodontics, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, São Paulo, SP, 222705508-000, Brazil.
Paulo Vinícius SoaresSchool of Dentistry, Department of Dental Materials, Federal University of Uberlândia, Av. Pará - 1720, Uberlândia, Minas Gerais, Brazil.
Ana Cecilia Correa AranhaSpecial Laboratory of Lasers in Dentistry (LELO), Department of Restorative Dentistry, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes 2227, São Paulo, SP, 05508-000, Brazil. acca@usp.br.ORCID http://orcid.org/0000-0002-5742-5283
Universidade de São Paulo · BRUniversidade Federal de Minas Gerais · BRUniversidade Federal de Uberlândia · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis randomized controlled trial aimed to evaluate different protocols for dentin hypersensitivity treatment with low-power lasers and desensitizing agents, and the association between low-power lasers and desensitizing agents. MATERIALS AND

methodsFifty-four patients (303 teeth) were randomly allocated to three groups: G1, 3% nitrate potassium gel, UltraEZ (n = 17); G2, photobiomodulation therapy (PBM) with a low-level infrared laser (n = 17), 100 mW, spot size of 0.028 cm

resultsThere was a reduction in pain levels at the end of treatment in all groups. There were no significant differences in VAS score changes between the groups immediately after treatment and after the third month, compared to the baseline (p > 0.05).

conclusionUnder the limitations of this in vivo study, the proposed three-session protocol was effective in reducing dentin hypersensitivity after 3 months, regardless of the desensitization mechanism used. Conservative and long-term protocols are interesting for the control of pain caused by dentin hypersensitivity. CLINICAL RELEVANCE: The increase in cervical dentin hypersensitivity prevalence warrants easy-to-apply and long-lasting desensitizing protocols for pain control.

Indexed as

Dentin Desensitizing AgentsDentin SensitivityLow-Level Light TherapyHumansNitratesPainPotassiumPotassium CompoundsTreatment OutcomeDentin Desensitizing AgentsNitratesPotassiumPotassium Compoundspotassium nitrateCervical dentin hypersensitivityClinical trialLow-power laserPotassium nitrate

Identifiers

PMID35871702
PMCPMC9309092
OpenAlexW4287009041

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.