Evidence map›Paper›PMID 35871600›Full record

Trial reportJournal of clinical periodontology2022

Recombinant human platelet-derived growth factor improves root coverage of a collagen matrix for multiple adjacent gingival recessions: A triple-blinded, randomized, placebo-controlled trial.

Lorenzo Tavelli, Shayan Barootchi, Maria Vera Rodriguez, Leonardo Mancini, Jad Majzoub, Suncica Travan, Jim Sugai, Hsun-Liang Chan, Oliver Kripfgans, Hom-Lay Wang and 1 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical periodontology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04462237 (The Effect of Recombinant Human Platelet-derived Growth Factor in Combination With Collagen Matrix for the Treatment of Multiple Adjacent Gingival Recessions), which is not on this map. Cited by 25 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 4 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04462237 nacompletednot on this map

The Effect of Recombinant Human Platelet-derived Growth Factor in Combination With Collagen Matrix for the Treatment of Multiple Adjacent Gingival Recessions: A Randomized Clinical Trial

TypeinterventionalSponsorUniversity of MichiganRan2020 to 2021Enrolled30ConditionsGingival Recession, Platelet Derived Growth FactorArmsRoot coverage procedures
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 37 citations in OpenAlex.

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  16. Ultrasonography-Guided Dental Implant Surgery: A Feasibility Study.Clinical implant dentistry and related research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Lorenzo TavelliDepartment of Oral Medicine, Infection, and Immunity, Division of Periodontology, Harvard School of Dental Medicine, Boston, Massachusetts, USA.ORCID 0000-0003-4864-3964
Shayan BarootchiDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.ORCID 0000-0002-5347-6577
Maria Vera RodriguezDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Leonardo ManciniDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.ORCID 0000-0002-7030-155X
Jad MajzoubDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Suncica TravanDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Jim SugaiDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Hsun-Liang ChanDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.ORCID 0000-0001-5952-0447
Oliver KripfgansBiointerfaces Institute and Department of Biomedical Engineering, College of Engineering, Ann Arbor, Michigan, USA.ORCID 0000-0003-2905-1496
Hom-Lay WangDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.ORCID 0000-0003-4238-1799
William V GiannobileDepartment of Oral Medicine, Infection, and Immunity, Division of Periodontology, Harvard School of Dental Medicine, Boston, Massachusetts, USA.ORCID 0000-0002-7102-9746
University of Michigan · USHarvard University · USUniversity of L'Aquila · IT

Funding

Delta Dental Foundation AWS015480
6 · The paper itself

Abstract

aimTo evaluate the efficacy of recombinant human platelet-derived growth factor (rhPDGF)-BB combined with a cross-linked collagen matrix (CCM) for the treatment of multiple adjacent gingival recession type 1 defects (MAGRs) in combination with the coronally advanced flap (CAF). MATERIALS AND

methodsThirty patients were enrolled in this triple-blind, randomized, placebo-controlled trial and treated with either CAF + CCM + rhPDGF, or CAF + CCM + saline. The primary outcome was mean root coverage (mRC) at 6 months. Complete root coverage, gain in gingival thickness (GT), keratinized tissue width, volumetric and ultrasonographic changes, and patient-reported outcome measures were also assessed. Mixed-modelling regression analyses were used for statistical comparisons.

resultsAt 6 months, the mRC of the CCM + rhPDGF and CCM alone groups were 88.25% and 77.72%, respectively (p = .02). A significant gain in GT was consistently observed for both treatment arms, and more so for the patients receiving the matrix containing rhPDGF through time (0.51 vs. 0.80 mm, on average, p = .01). The rhPDGF + CCM treated patients presented greater volume gain, higher soft tissue thickness, and a superior aesthetic score.

conclusionrhPDGF enhances the clinical, volumetric, and aesthetic outcomes of MAGRs above the results achieved with CAF + CCM alone (ClinicalTrials.gov NCT04462237).

Indexed as

Gingival RecessionCollagenConnective TissueEsthetics, DentalHumansPlatelet-Derived Growth FactorTreatment OutcomeCollagenPlatelet-Derived Growth Factorcollagen matrixgingival recessionplatelet-derived growth factorrandomized clinical trialroot coverage

Identifiers

PMID35871600
PMCPMC9796054
OpenAlexW4286945678

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.