ArticleJournal of epidemiology2023
Vitamin K Intake and Risk of Lung Cancer: The Japan Collaborative Cohort Study.
Article in Journal of epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Analysis and prediction of the burden of lung cancer attributable to diet low in fruits in China and the global from 1990 to 2021.PloS one · 2026Article
- Bio-Functional Nanomaterials for Enhanced Lung Cancer Therapy: The Synergistic Roles of Vitamins D and K.Journal of functional biomaterials · 2025Review
- Vitamin K: Metabolism, Genetic Influences, and Chronic Disease Outcomes.Food science & nutrition · 2025Review
- Disease burden of lung cancer attributable to metabolic and behavioral risks in China and globally from 1990 to 2021.BMC public health · 2025Article
- Vitamin K Properties in Stroke and Alzheimer's Disease: A Janus Bifrons in Protection and Prevention.Molecules (Basel, Switzerland) · 2025Review
- Dietary nutrient intake and cancer presence: evidence from a cross-sectional study.Frontiers in nutrition · 2025Article
- Vitamins and minerals and their role in cancer: a comprehensive review.Frontiers in nutrition · 2025Review
- Fat-soluble Vitamins and Lung Cancer: Where We Are?Recent patents on anti-cancer drug discovery · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLimited reports from prospective human studies investigated the possible role of vitamin K in the development of lung cancer although vitamin K's anticarcinogenic activities were verified from several in vitro and in vivo studies. We investigated the associations between total vitamin K intake from food and the development of lung cancer based on this large prospective cohort study.
methodsA validated food frequency questionnaire was used to examine vitamin K intake among 42,166 (16,341 men and 25,825 women) at the Japan Collaborative Cohort Study's baseline (1988-1990). Hazard ratios (HRs) and 95% confidence intervals (CIs) of incident lung cancer were calculated using the Cox proportional hazard regression method based on vitamin K consumption quartiles.
results430 cases (308 males and 122 women) of lung cancer were documented during a total of 564,127 person-years of follow-up (median follow-up, 14.6 years). Vitamin K consumption was shown to be inversely related to lung cancer risk; the multivariable hazard ratio [HR] for the highest versus lowest quartiles was 0.67 (95% confidence interval [CI], 0.46-0.96; P for trend = 0.010). This relationship appears to be stronger in males (HR 0.62; 95% CI, 0.40-0.96; P for trend = 0.016) than in females (HR 0.82; 95% CI, 0.42-1.61; P for trend = 0.39) (P for interaction = 0.012), and in ever smokers (HR 0.57; 95% CI, 0.36-0.91; P for trend = 0.006) than in never smokers (HR 0.79; 95% CI, 0.40-1.55; P for trend = 0.37) (P for interaction = 0.30). The individuals' age, body mass index, or alcohol consumption status had no effect on the observed connection.
conclusionVitamin K consumption reduces the risk of lung cancer. More research is needed to clarify the molecular processes behind this connection.
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