Evidence map›Paper›PMID 35871330›Full record

ArticleJournal of Alzheimer's disease : JAD2022

Episodic Memory, Hippocampal Volume, and Function for Classification of Mild Cognitive Impairment Patients Regarding Amyloid Pathology.

Eliane Correa Miotto, Sonia Maria Dozzi Brucki, Carlos T Cerqueira, Paulo R Bazán, Geise Aline de Almeida Silva, Maria da Graça M Martin, Paula Squarzoni da Silveira, Daniele de Paula Faria, Artur Martins Coutinho, Carlos Alberto Buchpiguel and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

Eliane Correa MiottoDepartment of Neurology, University of São Paulo, São Paulo, Brazil.
Sonia Maria Dozzi BruckiDepartment of Neurology, University of São Paulo, São Paulo, Brazil.
Carlos T CerqueiraDepartment of Psychiatry, University of Sao Paulo, São Paulo, Brazil.
Paulo R BazánInstitute of Radiology, LIM-44, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.
Geise Aline de Almeida SilvaDepartment of Neurology, University of São Paulo, São Paulo, Brazil.
Maria da Graça M MartinInstitute of Radiology, LIM-44, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.
Paula Squarzoni da SilveiraDepartment of Psychiatry, University of Sao Paulo, São Paulo, Brazil.
Daniele de Paula FariaLaboratory of Nuclear Medicine, LIM 43, Department of Radiology and Oncology, University of Sao Paulo, São Paulo, Brazil.
Artur Martins CoutinhoLaboratory of Nuclear Medicine, LIM 43, Department of Radiology and Oncology, University of Sao Paulo, São Paulo, Brazil.
Carlos Alberto BuchpiguelLaboratory of Nuclear Medicine, LIM 43, Department of Radiology and Oncology, University of Sao Paulo, São Paulo, Brazil.
Geraldo Busatto FilhoDepartment of Psychiatry, University of Sao Paulo, São Paulo, Brazil.
Ricardo NitriniDepartment of Neurology, University of São Paulo, São Paulo, Brazil.
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies of hippocampal function and volume related to episodic memory deficits in patients with amnestic mild cognitive impairment (aMCI) have produced mixed results including increased or decreased activity and volume. However, most of them have not included biomarkers, such as amyloid-β (Aβ) deposition which is the hallmark for early identification of the Alzheimer's disease continuum.

objectiveWe investigated the role of Aβ deposition, functional hippocampal activity and structural volume in aMCI patients and healthy elderly controls (HC) using a new functional MRI (fMRI) ecological episodic memory task.

methodsForty-six older adults were included, among them Aβ PET PIB positive (PIB+) aMCI (N = 17), Aβ PET PIB negative (PIB-) aMCI (N = 15), and HC (N = 14). Hippocampal volume and function were analyzed using Freesurfer v6.0 and FSL for news headlines episodic memory fMRI task, and logistic regression for group classification in conjunction with episodic memory task and traditional neuropsychological tests.

resultsThe aMCI PIB+ and PIB-patients showed significantly worse performance in relation to HC in most traditional neuropsychological tests and within group difference only on story recall and the ecological episodic memory fMRI task delayed recall. The classification model reached a significant accuracy (78%) and the classification pattern characterizing the PIB+ included decreased left hippocampal function and volume, increased right hippocampal function and volume, and worse episodic memory performance differing from PIB-which showed increased left hippocampus volume.

conclusionThe main findings showed differential neural correlates, hippocampal volume and function during episodic memory in aMCI patients with the presence of Aβ deposition.

Indexed as

Alzheimer DiseaseAmyloidosisCognitive DysfunctionMemory, EpisodicAgedAmyloidAmyloid beta-PeptidesHippocampusHumansMagnetic Resonance ImagingNeuropsychological TestsAmyloidAmyloid beta-PeptidesAmyloid-betaepisodic memoryfunctional magnetic resonancehippocampal volumemild cognitive impairment

Identifiers

PMID35871330
PMCPMC9484090
OpenAlexW4285803926

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.