Evidence map›Paper›PMID 35871265›Full record

ArticleAdvanced healthcare materials2022

X-Ray Markers for Thin Film Implants.

Ben J Woodington, Lawrence Coles, Amy E Rochford, Paul Freeman, Stephen Sawiak, Stephen J K O'Neill, Oren A Scherman, Damiano G Barone, Christopher M Proctor, George G Malliaras

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. In vivo microelectrode arrays for neuroscience.Nature reviews. Methods primers · 2025
    Article
  3. Article
  4. Review
  5. X-Ray Markers for Thin Film Implants.Advanced healthcare materials · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ben J WoodingtonElectrical Engineering Division, Department of Engineering, University of Cambridge, Cambridge, CB3 0FA, UK.
Lawrence ColesElectrical Engineering Division, Department of Engineering, University of Cambridge, Cambridge, CB3 0FA, UK.
Amy E RochfordElectrical Engineering Division, Department of Engineering, University of Cambridge, Cambridge, CB3 0FA, UK.
Paul FreemanDepartment of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK.
Stephen SawiakDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.
Stephen J K O'NeillMelville Laboratory for Polymer Synthesis, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
Oren A SchermanMelville Laboratory for Polymer Synthesis, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
Damiano G BaroneElectrical Engineering Division, Department of Engineering, University of Cambridge, Cambridge, CB3 0FA, UK.
Christopher M ProctorElectrical Engineering Division, Department of Engineering, University of Cambridge, Cambridge, CB3 0FA, UK.
George G MalliarasElectrical Engineering Division, Department of Engineering, University of Cambridge, Cambridge, CB3 0FA, UK.ORCID 0000-0002-4582-8501
University of Cambridge · GB

Funding

Biotechnology and Biological Sciences Research CouncilDepartment of Health CL-2019-14-004Medical Research Council RG84584
6 · The paper itself

Abstract

Implantable electronic medical devices are used in functional mapping of the brain before surgery and to deliver neuromodulation for the treatment of neurological and neuropsychiatric disorders. Their electrode arrays are assembled by hand, and this leads to bulky form factors with limited flexibility and low electrode counts. Thin film implants, made using microfabrication techniques, are emerging as an attractive alternative, as they offer dramatically improved conformability and enable high density recording and stimulation. A major limitation of these devices, however, is that they are invisible to fluoroscopy, the most common method used to monitor the insertion of implantable electrodes. Here, the development of mechanically flexible X-ray markers using bismuth- and barium-infused elastomers is reported. Their X-ray attenuation properties in human cadavers are explored and it is shown that they are biocompatible in cell cultures. It is further shown that they do not distort magnetic resonance imaging images and their integration with thin film implants is demonstrated. This work removes a key barrier for the adoption of thin film implants in brain mapping and in neuromodulation.

Indexed as

BismuthElastomersBariumElectrodes, ImplantedHumansX-RaysBariumBismuthElastomersbioelectronicsimagingmaterialsneuroscienceX-ray

Identifiers

PMID35871265
PMCPMC11468128
OpenAlexW4286790025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.