Evidence map›Paper›PMID 35871252›Full record

ArticleCommunications biology2022

Two-pore channel blockade by phosphoinositide kinase inhibitors YM201636 and PI-103 determined by a histidine residue near pore-entrance.

Canwei Du, Xin Guan, Jiusheng Yan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Tick-Derived Peptide Blocks Potassium Channel TREK-1.International journal of molecular sciences · 2024
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Canwei DuDepartment of Anesthesiology & Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Xin GuanDepartment of Anesthesiology & Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jiusheng YanDepartment of Anesthesiology & Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jyan1@mdanderson.org.ORCID 0000-0002-6633-1799
The University of Texas MD Anderson Cancer Center · US

Funding

Molecular basis of the NAADP-gated calcium release channel complexes - Equipment SupplementR01GM130814 · NIGMS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI YAN, JIUSHENG · 2018 to 2025
$2.6M
NIGMS NIH HHS R01 GM130814U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM130814
6 · The paper itself

Abstract

Human two-pore channels (TPCs) are endolysosomal cation channels and play an important role in NAADP-evoked Ca

Indexed as

Calcium ChannelsPhosphatidylinositols1-Phosphatidylinositol 4-KinaseAminopyridinesCalciumFuransHeterocyclic Compounds, 3-RingHistidineHumansPyridinesPyrimidines1-Phosphatidylinositol 4-Kinase6-amino-N-(3-(4-(4-morpholinyl)pyrido(3',2'-4,5)furo(3,2-d)pyrimidin-2-yl)phenyl)-3-pyridinecarboxamideAminopyridinesCalciumCalcium ChannelsFuransHeterocyclic Compounds, 3-RingHistidinePhosphatidylinositolsPI103PyridinesPyrimidines

Identifiers

PMID35871252
PMCPMC9308409
OpenAlexW4286750382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.