Evidence map›Paper›PMID 35871157›Full record

ArticleScientific reports2022

Antiviral activity of ouabain against a Brazilian Zika virus strain.

Deyse Cristina Madruga Carvalho, Poliana Gomes da Silva, Willyenne Marília Dantas, Severino Jefferson Ribeiro da Silva, Caroline Targino Alves da Silva, Elton José Ferreira Chaves, Demetrius Antônio Machado de Araújo, Ronaldo Nascimento de Oliveira, Sandra Rodrigues-Mascarenhas, Lindomar José Pena

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Steroid hormone ouabain cooperates with NaActa pharmaceutica Sinica. B · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Antiviral and immunomodulatory effects of ouabain against congenital Zika syndrome model.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  6. Review
  7. Sensational site: the sodium pump ouabain-binding site and its ligands.American journal of physiology. Cell physiology · 2024
    Review
  8. Review
  9. Identification of NaInternational journal of molecular sciences · 2023
    Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Deyse Cristina Madruga CarvalhoLaboratory of Immunobiotechnology, Biotechnology Center, Federal University of Paraiba (UFPB), João Pessoa, Paraiba, Brazil.
Poliana Gomes da SilvaDepartment of Virology and Experimental Therapy, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (Fiocruz), Recife, Pernambuco, Brazil.
Willyenne Marília DantasDepartment of Virology and Experimental Therapy, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (Fiocruz), Recife, Pernambuco, Brazil.
Severino Jefferson Ribeiro da SilvaDepartment of Virology and Experimental Therapy, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (Fiocruz), Recife, Pernambuco, Brazil.
Caroline Targino Alves da SilvaDepartment of Virology and Experimental Therapy, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (Fiocruz), Recife, Pernambuco, Brazil.
Elton José Ferreira ChavesLaboratory of Molecular and Cellular Biotechnology, Department of Biotechnology, Federal University of Paraiba (UFPB), João Pessoa, Paraiba, Brazil.
Demetrius Antônio Machado de AraújoLaboratory of Molecular and Cellular Biotechnology, Department of Biotechnology, Federal University of Paraiba (UFPB), João Pessoa, Paraiba, Brazil.
Ronaldo Nascimento de OliveiraDepartment of Chemistry, Federal Rural University of Pernambuco (UFRPE), Recife, Pernambuco, Brazil.
Sandra Rodrigues-MascarenhasLaboratory of Immunobiotechnology, Biotechnology Center, Federal University of Paraiba (UFPB), João Pessoa, Paraiba, Brazil. sandra@cbiotec.ufpb.br.
Lindomar José PenaDepartment of Virology and Experimental Therapy, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (Fiocruz), Recife, Pernambuco, Brazil. lindomar.pena@fiocruz.br.
Fundação Oswaldo Cruz · BRUniversidade Federal da Paraíba · BRUniversidade Federal Rural de Pernambuco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zika virus (ZIKV) is an emerging arbovirus associated with neurological disorders. Currently, no specific vaccines or antivirals are available to treat the ZIKV infection. Ouabain, a cardiotonic steroid known as Na

Indexed as

Cardiac GlycosidesZika VirusZika Virus InfectionAnimalsAntiviral AgentsBrazilChlorocebus aethiopsOuabainVero CellsVirus ReplicationAntiviral AgentsCardiac GlycosidesOuabain

Identifiers

PMID35871157
PMCPMC9308787
OpenAlexW4286715818

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.