Evidence map›Paper›PMID 35871126›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2022

IL-6 secretion of CD4

Xiu-Lin Zhu, Hao-Jue Wang, Xu-Ru Wang, Di Wu, Xuan Ji, Li Xu, Qi Yang, Jie-Ying Guo, Yan Rong, Ning Pan and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Effect of Extracellular Vesicles Derived From Tumor Cells on Immune Evasion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Xiu-Lin Zhu *Department of Microbiology and Immunology, Medical School of Southeast University, 87 Dingjiaqiao Rd., Nanjing, 210009, Jiangsu, China.
Hao-Jue Wang *Department of Obstetrics and Gynecology, Xishan People's Hospital of Wuxi City, 1128 Dacheng Rd., Wuxi, 214000, Jiangsu, China.
Xu-Ru WangDepartment of Microbiology and Immunology, Medical School of Southeast University, 87 Dingjiaqiao Rd., Nanjing, 210009, Jiangsu, China.
Di WuDepartment of Obstetrics and Gynecology, Zhongda Hospital, Medical School of Southeast University, 87 Dingjiaqiao Rd., Nanjing, 210009, Jiangsu, China.
Xuan JiDepartment of Microbiology and Immunology, Medical School of Southeast University, 87 Dingjiaqiao Rd., Nanjing, 210009, Jiangsu, China.
Li XuDepartment of Microbiology and Immunology, Medical School of Southeast University, 87 Dingjiaqiao Rd., Nanjing, 210009, Jiangsu, China.
Qi YangDepartment of Microbiology and Immunology, Medical School of Southeast University, 87 Dingjiaqiao Rd., Nanjing, 210009, Jiangsu, China.
Jie-Ying GuoDepartment of Microbiology and Immunology, Medical School of Southeast University, 87 Dingjiaqiao Rd., Nanjing, 210009, Jiangsu, China.
Yan RongDepartment of Microbiology and Immunology, Medical School of Southeast University, 87 Dingjiaqiao Rd., Nanjing, 210009, Jiangsu, China.
Ning PanDepartment of Microbiology and Immunology, Medical School of Southeast University, 87 Dingjiaqiao Rd., Nanjing, 210009, Jiangsu, China. 872794287@qq.com.
Yun-Lang CaiDepartment of Obstetrics and Gynecology, Zhongda Hospital, Medical School of Southeast University, 87 Dingjiaqiao Rd., Nanjing, 210009, Jiangsu, China. caiyl2021@163.com.ORCID http://orcid.org/0000-0002-4143-1785
Southeast University · CNZhongda Hospital Southeast University · CNWuxi People's Hospital · CN

Funding

National Natural Science Foundation of China 8187101983
6 · The paper itself

Abstract

backgroundOvarian cancer (OC) as the most fatal gynecological malignancy worldwide, with epithelial ovarian cancer (EOC) being the predominant and most lethal form, poses a serious threat to human health. LC3-positive extracellular vesicles (LC3

Indexed as

CD4-Positive T-LymphocytesExtracellular VesiclesOvarian NeoplasmsAnimalsAscitesCarcinoma, Ovarian EpithelialFemaleHeat-Shock ProteinsHumansInterleukin-10Interleukin-4Interleukin-6MiceMicrotubule-Associated ProteinsT-LymphocytesTransforming Growth Factor betaHeat-Shock ProteinsIL6 protein, humanInterleukin-10Interleukin-4Interleukin-6MAP1LC3A protein, humanMicrotubule-Associated ProteinsTransforming Growth Factor betaCD4+ T cellsEpithelial ovarian cancer (EOC)Heat shock protein 90α (HSP90α)IL-6LC3-positive extracellular vesicles (LC3+ EVs)

Identifiers

PMID35871126
OpenAlexW4286775978

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.