Evidence map›Paper›PMID 35871114›Full record

ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2022

Transplanting thoracic COVID-19 positive donors: An institutional protocol and report of the first 14 cases.

Emily M Eichenberger, Amanda C Coniglio, Carmelo Milano, Jacob Schroder, Benjamin S Bryner, Philip J Spencer, John C Haney, Jacob Klapper, Carolyn Glass, Elizabeth Pavlisko and 5 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Non-Standard Risk Donors and Risk of Donor-Derived Infections: From Evaluation to Therapeutic Management.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
  8. Acceptance of Organs from Deceased Donors With Resolved or Active SARS-CoV-2 Infection: A Survey From the Council of Europe.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Article
  9. Article
  10. Article
  11. Heart Transplant: Challenge Accepted.Journal of the American College of Cardiology · 2023
    Article
  12. Early Outcomes of Adult Heart Transplantation From COVID-19 Infected Donors.Journal of the American College of Cardiology · 2023
    Article
  13. Utilization of COVID-19 positive donors for Heart transplantation and associated short-term outcomes.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023
    Article
  14. Review
  15. Article
  16. Comparative outcomes for over 100 deceased donor kidney transplants from SARS-CoV-2 positive donors: A single-center experience.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  17. Low risk high reward: What should we worry about with coronavirus disease 2019 positive donors?Transplant infectious disease : an official journal of the Transplantation Society · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Emily M EichenbergerDivision of Transplant Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Amanda C ConiglioDivision of Transplant Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Carmelo MilanoDivision of Cardiothoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Jacob SchroderDivision of Cardiothoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Benjamin S BrynerDivision of Cardiothoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Philip J SpencerDivision of Cardiothoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
John C HaneyDivision of Cardiothoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Jacob KlapperDivision of Cardiothoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Carolyn GlassDepartment of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
Elizabeth PavliskoDepartment of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
Louis DibernardoDepartment of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
Chetan B PatelDivision of Transplant Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Adam D DeVoreDivision of Transplant Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
John ReynoldsDivision of Transplant Pulmonology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Cameron R WolfeDivision of Transplant Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA. Electronic address: cw74@duke.edu.
Duke Medical Center · USDuke University · US

Funding

Transplant Infectious Diseases Interdisciplinary Research Training Grant (TIDIRTGT32AI100851 · NIAID · DUKE UNIVERSITY · PI ALEXANDER, BARBARA D · 2013 to 2022
$1.8M
NIAID NIH HHS T32 AI100851
6 · The paper itself

Abstract

We present our institution's protocol for evaluating and transplanting thoracic organs from COVID-19 positive donors and report the outcomes to date. Hearts from donors testing positive for COVID-19 on any test were eligible for transplantation at our institution provided the donor exhibited no evidence of hypercoagulability or COVID-19 induced hyperinflammatory state during terminal hospitalization. Lungs were eligible if the donor first tested PCR positive on nasopharyngeal swab (NPS) for COVID-19 > 20 days prior to procurement and had a negative lower respiratory tract specimen. We performed 14 thoracic transplants in 13 recipients using organs from COVID-19 positive donors. None of the recipients or healthcare members acquired COVID-19. No recipients suffered unexpected acute rejection. Patient survival is 92% to date, with graft survival 93%. The use of hearts from COVID-19 positive donors may be safe and effective. Transplantation of lungs is unresolved but may be cautiously pursued under the restricted circumstances.

Indexed as

COVID-19Lung TransplantationTissue and Organ ProcurementGraft SurvivalHumansTissue DonorsCOVID-19donor-derived infectionheart transplantlung Transplantorgan donation

Identifiers

PMID35871114
PMCPMC9245398
OpenAlexW4283715313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.