Evidence map›Paper›PMID 35871112›Full record

ArticleActa neuropathologica2022

Regional distribution and maturation of tau pathology among phenotypic variants of Alzheimer's disease.

Sanaz Arezoumandan, Sharon X Xie, Katheryn A Q Cousins, Dawn J Mechanic-Hamilton, Claire S Peterson, Camille Y Huang, Daniel T Ohm, Ranjit Ittyerah, Corey T McMillan, David A Wolk and 6 more

Open access · greenAbstract read
In one paragraph

Article in Acta neuropathologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  9. Review
  10. Article
  11. Article
  12. Article
  13. Hippocampal tau distribution in primary age-related tauopathy: The Vantaa 85+ Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  14. Review
  15. Article
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  17. Article
  18. Article
  19. Article
  20. Co-pathologies modify hippocampal protein accumulation patterns in neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Sanaz ArezoumandanDigital Neuropathology Laboratory, Department of Neurology, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Sharon X XieDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Katheryn A Q CousinsPenn Frontotemporal Degeneration Center, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Dawn J Mechanic-HamiltonDepartment of Neurology, Penn Memory Center, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Claire S PetersonDigital Neuropathology Laboratory, Department of Neurology, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Camille Y HuangDigital Neuropathology Laboratory, Department of Neurology, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Daniel T OhmDigital Neuropathology Laboratory, Department of Neurology, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Ranjit IttyerahPenn Image Computing and Science Lab, Department of Radiology, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Corey T McMillanPenn Frontotemporal Degeneration Center, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
David A WolkDepartment of Neurology, Penn Memory Center, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Paul YushkevichDepartment of Neurology, Penn Alzheimer's Disease Research Center, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
John Q TrojanowskiDepartment of Neurology, Penn Alzheimer's Disease Research Center, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Edward B LeeDepartment of Neurology, Penn Alzheimer's Disease Research Center, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Murray GrossmanPenn Frontotemporal Degeneration Center, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Jeffrey S PhillipsPenn Frontotemporal Degeneration Center, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
David J IrwinDigital Neuropathology Laboratory, Department of Neurology, Perelman School of Medicine, Philadelphia, PA, 19104, USA. dirwin@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-5599-5098
University of Pennsylvania · USInstitute for Neurodegenerative Disorders · USPenn Center for AIDS Research · US

Funding

UPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DETRE, JOHN A · 1991 to 2020
$35.1M
Research Education ComponentP30AG072979 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVID A WOLK · 2021 to 2026
$24.8M
Understanding Environmental Contributions to Heterogeneity in bvFTD.P01AG066597 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Lauren M Massimo · 2020 to 2026
$18.8M
Project IV "Tackling Heterogeneity of Cognitive Trajectory in LBD"U19AG062418 · NIA · UNIVERSITY OF PENNSYLVANIA · PI CHEN-PLOTKIN, ALICE S · 2019 to 2023
$18.1M
Spreading Tau Pathology in Non-Amnestic Alzheimer's DiseaseR01AG054519 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jeffrey S Phillips · 2018 to 2026
$7.4M
Microscopic and Large-Scale Networks of Molecular Pathology in Frontotemporal Lobar DegenerationR01NS109260 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI IRWIN, DAVID JOHN · 2019 to 2023
$3.8M
Development of a Mobile Cognitive App for Detecting and Monitoring Change in Preclinical Alzheimer's DiseaseK23AG065499 · NIA · UNIVERSITY OF PENNSYLVANIA · PI MECHANIC-HAMILTON, DAWN J · 2020 to 2024
$884k
A Network Neuroscience Investigation of Disease Spread in Non-Amnestic Mild Cognitive ImpairmentK01AG061277 · NIA · UNIVERSITY OF PENNSYLVANIA · PI PHILLIPS, JEFFREY S · 2019 to 2023
$583k
NIA NIH HHS K01 AG061277NIA NIH HHS K23 AG065499NIA NIH HHS P01 AG066597NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG072979NIA NIH HHS R01 AG054519NIA NIH HHS U19 AG062418NINDS NIH HHS R01 NS109260
6 · The paper itself

Abstract

Alzheimer's disease neuropathologic change (ADNC) is clinically heterogenous and can present with a classic multidomain amnestic syndrome or focal non-amnestic syndromes. Here, we investigated the distribution and burden of phosphorylated and C-terminally cleaved tau pathologies across hippocampal subfields and cortical regions among phenotypic variants of Alzheimer's disease (AD). In this study, autopsy-confirmed patients with ADNC, were classified into amnestic (aAD, N = 40) and non-amnestic (naAD, N = 39) groups based on clinical criteria. We performed digital assessment of tissue sections immunostained for phosphorylated-tau (AT8 detects pretangles and mature tangles), D

Indexed as

Alzheimer DiseaseHippocampusHumansNeurofibrillary Tanglestau ProteinsTemporal Lobetau ProteinsAlzheimer’s diseaseNeurofibrillary tanglesNon-amnestic ADTau

Identifiers

PMID35871112
PMCPMC9936795
OpenAlexW4286762230

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.