SynthesisSystematic reviews2022
AMSTAR 2 appraisal of systematic reviews and meta-analyses in the field of heart failure from high-impact journals.
Synthesis in Systematic reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 14 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 14 syntheses or guidelines pooled it.
- The Factors That Contribute to Dysfunctional Behavior in Active Military Personnel: An Umbrella Review.Trauma, violence & abuse · 2026Pooled it
- Classroom Movement Breaks in Relation to Health and Academic Outcomes: An Umbrella Review.The Journal of school health · 2026Pooled it
- Pharmacological therapies for neglected tropical diseases: a systematic review and evidence gap mapping.Revista da Sociedade Brasileira de Medicina Tropical · 2026Pooled it
- Methodological Quality of Systematic Reviews on Treatments for Gastric Cancer: A Cross-Sectional Study.Digestive surgery · 2026Pooled it
- Overview of Systematic Reviews on Treatments for Pulmonary Arterial Hypertension: Assessing Methodological Quality and Mapping Evidence Gaps.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2025Pooled it
- Universal, selective and indicated parenting interventions to prevent the development of adverse mental health outcomes in youth: a meta-review of systematic reviews.BMJ mental health · 2025Pooled it
- Understanding turnover in healthcare and welfare sectors of high-income countries: an umbrella review.BMC health services research · 2025Pooled it
- Improving medication adherence in the community: a purposive umbrella review of effective patient-directed interventions that are readily implementable in the United Kingdom National Health Service.International journal of clinical pharmacy · 2025Pooled it
- Statin use and risk of HCC in patients with MASLD and T2DM: an umbrella review and meta-analysis.BMC cancer · 2025 · on this mapPooled it
- Clinical effectiveness of Zirconia versus titanium dental implants in anterior region: an overview of systematic reviews.European journal of medical research · 2025Pooled it
- Could the use of web-based applications assist in neuropsychiatric treatment? An umbrella review.BMC psychology · 2025Pooled it
- Reporting and methodological quality of systematic reviews underpinning clinical practice guidelines for low back pain: a meta-epidemiological study.Frontiers in pain research (Lausanne, Switzerland) · 2025Pooled it
- A meta-analysis of systematic reviews and meta-analyses to evaluate the psychological consequences of COVID-19.BMC psychology · 2023Pooled it
- Pooled it
- Anti-Amyloid Antibodies in the Treatment of Alzheimer's Disease: An Umbrella Review.Journal of clinical medicine · 2026Review
- Lower-limb biomechanical alterations across movement tasks in individuals with chronic ankle instability: An umbrella review of systematic reviews and meta-analyses.Mechanobiology in medicine · 2026Review
- Can artificial intelligence accurately assess systematic review quality? Benchmarking large language models for AMSTAR 2 appraisal in dental evidence synthesis.Evidence-based dentistry · 2026Article
- Review
- Traditional Chinese medicine for pediatric adenoid hypertrophy: an Umbrella review of methodological, reporting, and evidence quality.Frontiers in allergy · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Measurement Tool to Assess systematic Reviews (AMSTAR) 2 is a critical appraisal tool for systematic reviews (SRs) and meta-analyses (MAs) of interventions. We aimed to perform the first AMSTAR 2-based quality assessment of heart failure-related studies.
methodsEleven high-impact journals were searched from 2009 to 2019. The included studies were assessed on the basis of 16 domains. Seven domains were deemed critical for high-quality studies. On the basis of the performance in these 16 domains with different weights, overall ratings were generated, and the quality was determined to be "high," "moderate," "low," or "critically low."
resultsEighty-one heart failure-related SRs with MAs were included. Overall, 79 studies were of "critically low quality" and two were of "low quality." These findings were attributed to insufficiency in the following critical domains: a priori protocols (compliance rate, 5%), complete list of exclusions with justification (5%), risk of bias assessment (69%), meta-analysis methodology (78%), and investigation of publication bias (60%).
conclusionsThe low ratings for these potential high-quality heart failure-related SRs and MAs challenge the discrimination capacity of AMSTAR 2. In addition to identifying certain areas of insufficiency, these findings indicate the need to justify or modify AMSTAR 2's rating rules.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.