Evidence map›Paper›PMID 35870900›Full record

ArticleBMC cancer2022

Metabolic activity determines survival depending on the level of lymph node involvement in cervical cancer.

Alejandra Martinez, Elodie Chantalat, Martina Aida Angeles, Gwénaël Ferron, Anne Ducassou, Manon Daix, Justine Attal, Sarah Bétrian, Amélie Lusque, Erwan Gabiache

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Alejandra MartinezSurgical Oncology Department. Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France. Martinez.alejandra@iuct-oncopole.fr.ORCID http://orcid.org/0000-0002-7633-3536
Elodie ChantalatGynecology Department. Centre Hospitalier, Universitaire de Toulouse. Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France.
Martina Aida AngelesSurgical Oncology Department. Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France.
Gwénaël FerronSurgical Oncology Department. Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France.
Anne DucassouRadiotherapy Department. Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France.
Manon DaixSurgical Oncology Department. Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France.
Justine AttalRadiotherapy Department. Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France.
Sarah BétrianMedical Oncology Department. Institut Claudius Regaud. Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France.
Amélie LusqueBiostatistics Department. Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France.
Erwan GabiacheNuclear Medicine Department. Institut Claudius Regaud. Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France.
Institut Claudius Regaud · FRInserm · FRCentre Hospitalier Universitaire de Toulouse · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo assess the impact of PET/CT functional parameters on survival, locoregional, and distant failure according to the most distant level of lymph node [

methodsRetrospective study including 148 patients with LACC treated with concurrent chemoradiotherapy after PET/CT and para-aortic lymph node (PALN) surgical staging. Two senior nuclear medicine physicians reviewed all PET/CT exams and retrieved tumor and lymph node metabolic parameters: SUVmax, MTV, TLG. Oncological outcomes according to metabolic parameters and level of lymph node spread on PET/CT were assessed.

resultsIn patients without lymph node uptake on PET/CT, high MTV values of the cervical tumor were associated with DFS (HR = 5.14 95%CI = [2.15-12.31]), OS (HR = 6.10 95%CI = [1.89-19.70]), and time to distant (HR = 4.73 95%CI = [1.55-14.44]) and locoregional recurrence (HR = 5.18 95%CI = [1.72-15.60]). In patients with pelvic lymph node (PLN) uptake but without PALN uptake on [

conclusionsCervical MTV is more accurate than SUVmax to predict survival outcome in patients with locoregional disease confined to the pelvis and should be implemented in routine clinical practice. Prognostic value of metabolic metrics disappears with PALN uptake, which is associated with distant failure in nearly half of patients.

Indexed as

Fluorodeoxyglucose F18Uterine Cervical NeoplasmsFemaleHumansLymph NodesNeoplasm Recurrence, LocalPositron-Emission TomographyPositron Emission Tomography Computed TomographyPrognosisRadiopharmaceuticalsRetrospective StudiesFluorodeoxyglucose F18RadiopharmaceuticalsFluorodeoxyglucose F18Locally advanced cervical cancerLymphatic metastasisPositron Emission Tomography Computed TomographySurvival AnalysisUterine Cervical Neoplasms

Identifiers

PMID35870900
PMCPMC9308355
OpenAlexW4286715928

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.