Evidence map›Paper›PMID 35870522›Full record

ArticleExperimental neurology2022

Characterization of non-alpha retinal ganglion cell injury responses reveals a possible block to restoring ipRGC function.

John L Hunyara, Sierra Foshe, Supraja G Varadarajan, Katherine D Gribble, Andrew D Huberman, Alex L Kolodkin

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

John L HunyaraThe Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Sierra FosheThe Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Supraja G VaradarajanDepartment of Neurobiology, Stanford University, Stanford, CA 94305, USA.
Katherine D GribbleThe Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Andrew D HubermanDepartment of Neurobiology, Stanford University, Stanford, CA 94305, USA; Department of Ophthalmology, Stanford University, Stanford, CA 94305, USA.
Alex L KolodkinThe Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: kolodkin@jhmi.edu.

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
Molecular and functional regeneration of the accessory optic pathwayR01EY027713 · NEI · JOHNS HOPKINS UNIVERSITY · PI HUBERMAN, ANDREW D, KOLODKIN, ALEX L · 2017 to 2020
$2.4M
Molecular mechanisms underlying direction-selective circuit assembly and function in the mouse visual systemR01EY032095 · NEI · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2021 to 2025
$2.3M
NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY027713NEI NIH HHS R01 EY032095
6 · The paper itself

Abstract

Visual impairment caused by retinal ganglion cell (RGC) axon damage or degeneration affects millions of individuals throughout the world. While some progress has been made in promoting long-distance RGC axon regrowth following injury, it remains unclear whether RGC axons can properly reconnect with their central targets to restore visual function. Additionally, the regenerative capacity of many RGC subtypes remains unknown in part due to a lack of available genetic tools. Here, we use a new mouse line, Sema6A

Indexed as

Optic Nerve InjuriesSemaphorinsAnimalsAxonsMiceMice, Inbred C57BLNerve CrushNerve RegenerationRetinaRetinal Ganglion CellsSema6a protein, mouseSemaphorinsAxon regenerationIntraretinal axonsipRGCsLin28On DSGCsRetinal ganglion cells

Identifiers

PMID35870522
PMCPMC9549754

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.