Evidence map›Paper›PMID 35870486›Full record

ArticleExperimental eye research2022

Pharmacokinetics and metabolism in mouse retina of bis-allylic deuterated docosahexaenoic acid (D-DHA), a new dry AMD drug candidate.

Genevieve James, Whitney Bohannan, Eniola Adewunmi, Karsten Schmidt, Hui Gyu Park, Mikhail S Shchepinov, Martin-Paul Agbaga, J Thomas Brenna

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  3. Journal of the American Chemical Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Genevieve JamesDell Pediatric Research Institute, University of Texas at Austin, Austin, TX, USA. Electronic address: gejames@utexas.edu.
Whitney BohannanDepartments of Cell Biology, 608 Stanton L, Young Blvd, Oklahoma City, OK, 73104, USA; Departments of Ophthalmology and Dean McGee Eye Institute, 608 Stanton L, Young Blvd, Oklahoma City, OK, 73104, USA; University of Oklahoma Health Sciences Center, 608 Stanton L, Young Blvd, Oklahoma City, OK, 73104, USA. Electronic address: Whitney-Bohannan@ouhsc.edu.
Eniola AdewunmiDepartments of Cell Biology, 608 Stanton L, Young Blvd, Oklahoma City, OK, 73104, USA; Departments of Ophthalmology and Dean McGee Eye Institute, 608 Stanton L, Young Blvd, Oklahoma City, OK, 73104, USA; University of Oklahoma Health Sciences Center, 608 Stanton L, Young Blvd, Oklahoma City, OK, 73104, USA. Electronic address: Eniola-Adewunmi@ouhsc.edu.
Karsten SchmidtRetrotope, Inc., 4300 El Camino Real, Suite 201, Los Altos, CA, 94022, USA. Electronic address: karsten.schmidt@retrotope.com.
Hui Gyu ParkDell Pediatric Research Institute, University of Texas at Austin, Austin, TX, USA. Electronic address: hi.park@austin.utexas.edu.
Mikhail S ShchepinovRetrotope, Inc., 4300 El Camino Real, Suite 201, Los Altos, CA, 94022, USA. Electronic address: misha@retrotope.com.
Martin-Paul AgbagaDepartments of Cell Biology, 608 Stanton L, Young Blvd, Oklahoma City, OK, 73104, USA; Departments of Ophthalmology and Dean McGee Eye Institute, 608 Stanton L, Young Blvd, Oklahoma City, OK, 73104, USA; University of Oklahoma Health Sciences Center, 608 Stanton L, Young Blvd, Oklahoma City, OK, 73104, USA. Electronic address: martin-paul-agbaga@ouhsc.edu.
J Thomas BrennaDell Pediatric Research Institute, University of Texas at Austin, Austin, TX, USA. Electronic address: tbrenna@austin.utexas.edu.
Dean McGee Eye Institute · USThe University of Texas at Austin · USRetrotope (United States) · US

Funding

P30-CENTER CORE GRANT FOR VISION RESEARCHP30EY021725 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Michelle C Callegan, MICHAEL H ELLIOTT · 2011 to 2026
$10.5M
Essential Role of Very Long Chain Fatty Acids in Retinal FunctionR01EY030513 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI AGBAGA, MARTIN-PAUL · 2019 to 2023
$1.8M
Defining the Mechanism of Altered Very Long Chain Fatty Acid Metabolism in Neuro-Ichthyotic Disorders.R21AR076035 · NIAMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI AGBAGA, MARTIN-PAUL · 2019 to 2020
$351k
NEI NIH HHS P30 EY021725NEI NIH HHS R01 EY030513NIAMS NIH HHS R21 AR076035
6 · The paper itself

Abstract

Docosahexaenoic acid (DHA; 22:6n-3) rich photoreceptors function in a highly oxidizing microenvironment. Lipid peroxidation and inflammation contribute to initiation and progression of eye diseases including age-related macular degeneration (AMD). Deuteration of DHA at the bis-allylic positions (D-DHA) increases its resilience to oxidative damage in vitro. We studied the pharmacokinetics of dietary D-DHA as a therapy for replacing natural retinal DHA in vivo. Mice were fed 0.5% D-DHA for 77 days then switched to natural DHA (H-DHA) for 74 days. Tissue were harvested for analyses at various time points. D-DHA substitution levels were 75%-80% in the CNS and above 90% in all other tissues by day 77. D-DHA accretion was rapid in plasma and liver (t

Indexed as

Docosahexaenoic AcidsGeographic AtrophyAnimalsLipid PeroxidationMiceOxidative StressRetinaDocosahexaenoic Acids

Identifiers

PMID35870486
PMCPMC11238729
OpenAlexW4286267891

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.