Evidence map›Paper›PMID 35870481›Full record

ArticleBiochimica et biophysica acta. Biomembranes2022

Purification and membrane interactions of human KCNQ1

Gunjan Dixit, Rebecca B Stowe, Alison Bates, Colleen K Jaycox, Jorge R Escobar, Benjamin D Harding, Daniel L Drew, Christopher P New, Indra D Sahu, Richard E Edelmann and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Biomembranes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. The role of native cysteine residues in the oligomerization of KCNQ1 channels.Biochemical and biophysical research communications · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Gunjan DixitDepartment of Chemistry and Biochemistry, Miami University, 651 E. High Street, Oxford, OH 45056, USA; Cell, Molecular and Structural Biology Program, Department of Chemistry & Biochemistry, Miami University, Oxford, OH 45056, USA.
Rebecca B StoweDepartment of Chemistry and Biochemistry, Miami University, 651 E. High Street, Oxford, OH 45056, USA.
Alison BatesDepartment of Chemistry and Biochemistry, Miami University, 651 E. High Street, Oxford, OH 45056, USA.
Colleen K JaycoxDepartment of Chemistry and Biochemistry, Miami University, 651 E. High Street, Oxford, OH 45056, USA.
Jorge R EscobarDepartment of Chemistry and Biochemistry, Miami University, 651 E. High Street, Oxford, OH 45056, USA; Cell, Molecular and Structural Biology Program, Department of Chemistry & Biochemistry, Miami University, Oxford, OH 45056, USA.
Benjamin D HardingDepartment of Chemistry and Biochemistry, Miami University, 651 E. High Street, Oxford, OH 45056, USA.
Daniel L DrewDepartment of Chemistry and Biochemistry, Miami University, 651 E. High Street, Oxford, OH 45056, USA.
Christopher P NewDepartment of Chemistry and Biochemistry, Miami University, 651 E. High Street, Oxford, OH 45056, USA; Cell, Molecular and Structural Biology Program, Department of Chemistry & Biochemistry, Miami University, Oxford, OH 45056, USA.
Indra D SahuDepartment of Chemistry and Biochemistry, Miami University, 651 E. High Street, Oxford, OH 45056, USA.
Richard E EdelmannCenter for Advanced Microscopy and Imaging, Miami University, Oxford, OH 45056, USA.
Carole Dabney-SmithDepartment of Chemistry and Biochemistry, Miami University, 651 E. High Street, Oxford, OH 45056, USA; Cell, Molecular and Structural Biology Program, Department of Chemistry & Biochemistry, Miami University, Oxford, OH 45056, USA.
Charles R SandersDepartment of Biochemistry and Center for Structural Biology, Vanderbilt University, Nashville, TN 37240, USA.
Gary A LoriganDepartment of Chemistry and Biochemistry, Miami University, 651 E. High Street, Oxford, OH 45056, USA; Cell, Molecular and Structural Biology Program, Department of Chemistry & Biochemistry, Miami University, Oxford, OH 45056, USA. Electronic address: gary.lorigan@miamioh.edu.
Miami University · USVanderbilt University · US

Funding

Decrypting Variants of Uncertain Significance in Long-QT SyndromeR01HL122010 · NHLBI · VANDERBILT UNIVERSITY · PI GEORGE, ALFRED L., SANDERS, CHARLES R · 2014 to 2025
$15.5M
EPR Spectroscopic Studies of Membrane Proteins-Diversity SupplementR35GM126935 · NIGMS · MIAMI UNIVERSITY OXFORD · PI GARY A LORIGAN · 2018 to 2026
$3.3M
NHLBI NIH HHS R01 HL122010NIGMS NIH HHS R35 GM126935
6 · The paper itself

Abstract

KCNQ1 (Kv7.1 or KvLQT1) is a voltage-gated potassium ion channel that is involved in the ventricular repolarization following an action potential in the heart. It forms a complex with KCNE1 in the heart and is the pore forming subunit of slow delayed rectifier potassium current (I

Indexed as

Long QT SyndromePotassium Channels, Voltage-GatedHumansKCNQ1 Potassium ChannelPotassiumPotassium ChannelsTandem Mass SpectrometryKCNQ1 Potassium ChannelKCNQ1 protein, humanPotassiumPotassium ChannelsPotassium Channels, Voltage-GatedK(+) channelKCNQ1Membrane proteinNMR

Identifiers

PMID35870481
PMCPMC11524546
OpenAlexW4286267391

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.